ArticleBiomolecules2026
Biological Interactions in Rat Tibial Osteogenesis: Micro-CT, Histomorphometric, and Histological Analyses of Bioglass, Fibrin Biopolymer, and Photobiomodulation.
Lívia Maluf Menegazzo Bueno, Livia Cristina Dias, Ana Carolina Cestari Bighetti, Camila Pascoal Correia Dos Santos, Benedito Barraviera, Rui Seabra Ferreira Júnior, Murilo Priori Alcalde, Marco Antonio Hungaro Duarte, Carlos Henrique Bertoni Reis, Daniela Vieira Buchaim and 1 more
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In one paragraphArticle in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
11 authors.
Lívia Maluf Menegazzo BuenoPostgraduate Program in Applied Dental Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, SP, Brazil.
Livia Cristina DiasDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, SP, Brazil.
Ana Carolina Cestari BighettiPostgraduate Program in Applied Dental Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, SP, Brazil.
Camila Pascoal Correia Dos SantosPostgraduate Program in Applied Dental Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, SP, Brazil.ORCID 0009-0005-3777-3298 Benedito BarravieraCenter for the Study of Venoms and Venomous Animals (Cevap), São Paulo State University (Univ. Estadual Paulista, UNESP), Botucatu 18610-307, SP, Brazil.ORCID 0000-0002-9855-5594 Rui Seabra Ferreira JúniorCenter for the Study of Venoms and Venomous Animals (Cevap), São Paulo State University (Univ. Estadual Paulista, UNESP), Botucatu 18610-307, SP, Brazil.ORCID 0000-0001-6952-0512 Murilo Priori AlcaldeDepartment of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, Brazil.
Marco Antonio Hungaro DuarteDepartment of Dentistry, Endodontics and Dental Materials, Bauru School of Dentistry (FOB/USP), University of São Paulo, Bauru 17012-901, SP, Brazil.ORCID 0000-0003-3051-737X Carlos Henrique Bertoni ReisUNIMAR Beneficent Hospital (HBU), University of Marília, Marília 17525-160, SP, Brazil.ORCID 0000-0001-9001-6345 Daniela Vieira BuchaimMedical School, University Center of Adamantina (FAI), Adamantina 17800-000, SP, Brazil.ORCID 0000-0002-9914-1262 Rogerio Leone BuchaimDepartment of Biological Sciences, Bauru School of Dentistry (FOB/USP), University of Sao Paulo, Bauru 17012-901, SP, Brazil.ORCID 0000-0002-5881-2218 Funding
Coordenação de Aperfeicoamento de Pessoal de Nível Superior Finance Code 001Fundação de Amparo à Pesquisa do Estado de São Paulo No 2021/11936-3; 2023/16514-5National Council for Scientific and Technological Development . 301608/2022-9; 302545/2025-5; 304153/2024-9
6 · The paper itselfAbstract
The study evaluated bone repair in tibial defects of Wistar rats treated with 45S5 bioactive glass, either alone or combined with lyophilized heterologous fibrin biopolymer (HFB) and/or photobiomodulation therapy (PBM). Thirty-five animals were randomly assigned to five groups: control (CG), Bioactive glass (BG), Bioactive glass + HFB (BFG), Bioactive glass + PBM (BPG), and Bioactive glass + HFB + PBM (BFPG). After 42 days, the samples were analyzed by micro-computed tomography, histology (Hematoxylin-Eosin, Masson's Trichrome, and Picrosirius Red), and histomorphometry. Histological and micro-CT findings demonstrated improved defect closure and better matrix organization in the BG and BFG groups. Histomorphometric analysis revealed significant differences among the groups (ANOVA,
Indexed as
CeramicsFibrinLow-Level Light TherapyOsteogenesisTibiaAnimalsBiopolymersBone RegenerationGlassMaleRatsRats, WistarX-Ray Microtomographybioactive glass 45S5BioglassBiopolymersFibrinbioactive glassbioglassbiomaterialsbone regenerationfibrin biopolymerfibrin sealantlow-level laser therapyphotobiomodulation
Identifiers
PMID42352250
PMCPMC13296436
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