Evidence map›Paper›PMID 42352238›Full record

ArticleBiomolecules2026

Spondin-1 Inhibits Odontoblastic Differentiation of Human Dental Pulp Stem Cells.

Bara Mardini, Hideki Sugii, Koudai Tashita, Mhd Safwan Albougha, Serina Soeno, Ryosuke Tachibana, Ömer Tarık Özdemir, Kanon Nasu, Sayuri Hamano, Hidefumi Maeda

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In one paragraph

Article in Biomolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Bara MardiniDepartment of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Hideki SugiiDepartment of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Koudai TashitaDepartment of Endodontology, Kyushu University Hospital, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
Mhd Safwan AlboughaDepartment of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Serina SoenoDepartment of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Ryosuke TachibanaDepartment of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Ömer Tarık ÖzdemirDepartment of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.ORCID 0009-0004-7232-6816
Kanon NasuDepartment of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Sayuri HamanoDepartment of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.
Hidefumi MaedaDepartment of Endodontology and Operative Dentistry, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan.ORCID 0000-0002-1347-995X

Funding

Japan Society for the Promotion of Science JP23K09171Japan Society for the Promotion of Science JP 23K24528Japan Society for the Promotion of Science JP26K12659Japan Society for the Promotion of Science JP26K12660
6 · The paper itself

Abstract

Reparative dentin formation is a defensive response that restores a mineralized barrier to protect the dental pulp following various stimuli, such as bacterial invasion, tooth preparation, or restorative materials. However, reparative dentin is limited, and to avoid pathological calcification or pulp canal obliteration, mineral deposition must be restricted to the injured area and temporally restrained once the barrier is reestablished. This suggests the existence of negative regulators that can halt odontoblastic differentiation; however, such inhibitory regulators remain incompletely defined. Spondin-1 (SPON1) is an extracellular matrix protein known to regulate bone homeostasis and act as a negative regulator of bone mass; however, the effects of SPON1 on odontoblastic differentiation of dental pulp stem cells (DPSCs) remain unclear. This study aimed to analyze the effects of SPON1 on odontoblastic differentiation of human DPSCs (HDPSCs). SPON1 was expressed in the odontoblastic layer and dental pulp tissue, and its expression was significantly decreased at the beginning of reparative dentin formation in rats. Treatment with SPON1 inhibited odontoblastic differentiation of HDPSCs by blocking the expression of non-phosphorylated β-catenin, while neutralizing SPON1 significantly enhanced odontoblastic differentiation of HDPSCs. These findings suggest that SPON1 functions as a negative regulator of odontoblastic differentiation during reparative dentin formation.

Indexed as

Cell DifferentiationDental PulpExtracellular Matrix ProteinsOdontoblastsStem CellsAnimalsbeta CateninCells, CulturedHumansRatsRats, Sprague-Dawleybeta CateninExtracellular Matrix ProteinsF-spondinhuman dental pulp stem cells (HDPSCs)mineralizationodontoblastic differentiationreparative dentin formationSPON1Wnt/β-catenin signaling

Identifiers

PMID42352238
PMCPMC13297351

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