DBCL-DFNet: Dual-Branch Contrastive Learning for Multi-Omics Dynamic Fusion.

Multimodal omics data portray biological processes across molecular layers, yet their heterogeneity and high dimensionality hinder a unified representation. Existing integrative approaches either focus on local feature interactions or adopt static fusion, often overlooking the complementary global sequential context and the dynamic relevance among omics sources. Consequently, clinically critical tasks such as accurate cancer-subtype classification and therapy selection still lack sufficient accuracy and robustness. We introduce the Dual-Branch Contrastive Learning for Multi-Omics Dynamic Fusion Network (DBCL-DFNet), a dual-branch contrastive-learning framework that simultaneously encodes local heterogeneous graphs and global omics sequences, distills key features via contrastive objectives, and employs a dynamic attention mechanism for adaptive, data-driven fusion. Benchmarked on three public cancer multi-omics datasets, DBCL-DFNet outperforms both conventional machine-learning models and state-of-the-art deep-integration methods, establishing a competitive and reliable framework for multi-omics integration and demonstrating potential for precision-oncology decision-making. From an information-theoretic perspective, the framework integrates Copula-entropy-guided feature selection with mutual-information-maximizing contrastive alignment, providing a principled foundation for robust multi-omics integration.