Evidence map›Paper›PMID 42352073›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Myeloid DRP1 Sulfenylation Drives Reparative Macrophage Polarization and Neovascularization in Ischemic Muscle.

Shikha Yadav, Rajagopal Kamarajan, Varadarajan Sudhahar, Sheela Nagarkoti, Archita Das, Stephanie Kelley Spears, Rajalakshmi Veeranan Karmegam, Tohru Fukai, Masuko Ushio-Fukai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Shikha YadavVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-8195-5700
Rajagopal KamarajanVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Varadarajan SudhaharVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-9675-0097
Sheela NagarkotiVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0002-3707-5036
Archita DasVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Stephanie Kelley SpearsVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0009-0003-3355-3111
Rajalakshmi Veeranan KarmegamVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Tohru FukaiVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-9864-571X
Masuko Ushio-FukaiVascular Biology Center, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0001-7048-2381

Funding

Sex and Leptin control of endothelial cell glycolysis and redox balance in Type 1 DiabetesP01HL160557 · NHLBI · AUGUSTA UNIVERSITY · PI TOHRU FUKAI, Masuko Ushio-Fukai · 2024 to 2026
$9.0M
Redox Regulation of Cu Importer CTR1 in AngiogenesisR01HL147550 · NHLBI · AUGUSTA UNIVERSITY · PI FUKAI, TOHRU, USHIO-FUKAI, MASUKO · 2020 to 2023
$3.3M
Cu uptake transporter as a disturbed flow sensor in vascular inflammatory diseaseR01HL174014 · NHLBI · AUGUSTA UNIVERSITY · PI TOHRU FUKAI, Masuko Ushio-Fukai · 2024 to 2026
$2.3M
Mitochondria Dynamics Protein Drp1 in ROS Signaling, Endothelial Metabolism and AngiogenesisR01HL160014 · NHLBI · AUGUSTA UNIVERSITY · PI USHIO-FUKAI, MASUKO · 2021 to 2024
$2.0M
American Heart Association 22TPA971863American Heart Association 23POST1022971American Heart Association 24CDA1273746BLRD VA I01 BX001232National Institute of Health R01HL174014NHLBI NIH HHS P01 HL160557NHLBI NIH HHS P01HL160557NHLBI NIH HHS R01HL147550NHLBI NIH HHS R01 HL160014NHLBI NIH HHS R01HL160014NHLBI NIH HHS R01 HL174014Veterans for America 2I01BX001232
6 · The paper itself

Abstract

Reparative macrophage polarization and macrophage-derived reactive oxygen species (ROS) are required for ischemia-induced revascularization in peripheral artery disease (PAD). Our previous study showed that mitochondrial fission protein dynamin-related protein 1 (DRP1) promotes reparative polarization and metabolic reprogramming in macrophages and post-ischemic neovascularization. However, the redox-dependent mechanism governing DRP1 activation in this context remains elusive. Here, using a mouse hindlimb ischemia (HLI) model of PAD, we identify cysteine sulfenylation (CysOH) of DRP1 as a critical redox modification induced in ischemic bone marrow (BM)-derived cells. BM chimeric mice reconstituted with CRISPR/Cas9-generated "redox-dead" DRP1-C631A knock-in mutant (

Indexed as

DRP1hindlimb ischemiainflammationmacrophagemetabolic reprogrammingmitochondrial fissionperipheral arterial diseasepost-translational modificationsulfenylation

Identifiers

PMID42352073
PMCPMC13295537

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.