Evidence map›Paper›PMID 42352046›Full record

ArticleAntioxidants (Basel, Switzerland)2026

Nitric Oxide, Reactive Oxygen Species, and Focal Adhesion Kinase Mediate Anoikis Resistance in A375 and SK-MEL-28 Human Melanoma Cells.

Igor R do Nascimento, Ana Caroline S Teodoro, Paulo V de Sousa, Leticia T Barboza, Joanderson P Cândido da Silva, Ricardo C Cintra, Caroline Alves, Lidia R De Toledo, Ronaldo J Carneiro, Luiz S Longo and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Anoikis: To Die or Not to Die?International journal of molecular sciences · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Igor R do NascimentoDepartment of Biochemistry, Center for Cellular and Molecular Therapy-CTCMol, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.
Ana Caroline S TeodoroDepartment of Biochemistry, Center for Cellular and Molecular Therapy-CTCMol, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.ORCID 0000-0002-8507-2964
Paulo V de SousaDepartment of Biochemistry, Center for Cellular and Molecular Therapy-CTCMol, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.
Leticia T BarbozaDepartment of Biochemistry, Center for Cellular and Molecular Therapy-CTCMol, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.
Joanderson P Cândido da SilvaDepartment of Biochemistry, Center for Cellular and Molecular Therapy-CTCMol, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.ORCID 0000-0003-2904-9492
Ricardo C CintraDepartment of Biochemistry, Center for Cellular and Molecular Therapy-CTCMol, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.
Caroline AlvesDepartment of Biochemistry, Center for Cellular and Molecular Therapy-CTCMol, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.
Lidia R De ToledoDepartment of Biochemistry, Center for Cellular and Molecular Therapy-CTCMol, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.
Ronaldo J CarneiroDepartment of Biochemistry, Center for Cellular and Molecular Therapy-CTCMol, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.ORCID 0009-0009-5464-1536
Luiz S LongoDepartment of Pharmaceutical Sciences, Campus Diadema, Universidade Federal de São Paulo, São Paulo 09913-030, Brazil.ORCID 0000-0001-6450-5700
Arnold SternGrossman School of Medicine, New York University, New York, NY 10016, USA.
Hugo P MonteiroDepartment of Biochemistry, Center for Cellular and Molecular Therapy-CTCMol, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.ORCID 0000-0003-1194-670X

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/15038-7Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/11297-8
6 · The paper itself

Abstract

Melanoma is a highly aggressive and invasive form of skin cancer that arises from the uncontrolled growth of melanocytes. It is characterized by early spread through the lymphatic system and metastasis. The success of metastasis is linked to the ability of melanoma and other cancer cells to resist anoikis, a type of cell death that occurs when cells lose their adhesion to the extracellular matrix. Redox signaling plays an essential role in anoikis resistance. The balance between intracellular levels of nitric oxide (NO) and the reactive oxygen species (ROS) O

Indexed as

anoikis resistancehydrogen peroxidemelanomaNADPH oxidase 4nitric oxideNO synthases

Identifiers

PMID42352046
PMCPMC13295398

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.