ReviewAntioxidants (Basel, Switzerland)2026
Cocoa-Based Plant Matrices in Glucose Metabolism: Bioactive Compounds and Redox Signaling.
Review in Antioxidants (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Polyphenol-rich cocoa in reducing diabetes-related pulmonary and vascular dysfunction: Protocol for a randomized controlled trial.International journal of cardiology. Cardiovascular risk and prevention · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cocoa-based foods are increasingly recognized as complex plant-derived matrices with potential relevance for metabolic health, driven by interactions among multiple bioactive components. Metabolic disorders, including insulin resistance and type 2 diabetes, are characterized by disturbances in glucose homeostasis, oxidative stress, and endothelial dysfunction. This narrative review critically examines the antidiabetic potential of cocoa-based plant matrices, integrating evidence from nutritional biochemistry and metabolic physiology. We analyze the specific role of cocoa flavanols in redox-sensitive signaling pathways related to nitric oxide bioavailability and insulin signaling. Furthermore, we evaluate how complementary matrix components, such as non-glycemic sweeteners, prebiotic and viscous fibers, oleic-rich lipids, and micronutrients, modulate postprandial glycemic responses, gut microbiota activity, and overall metabolic regulation. Current evidence indicates that the metabolic effects of cocoa cannot be attributed to isolated compounds but emerge from coordinated interactions within the food matrix. Understanding these multi-component dynamics is essential for the rational design of cocoa-based functional foods aimed at improving glycemic control and supporting metabolic resilience.
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Registered trials
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