ArticleBioengineering (Basel, Switzerland)2026
Targeting Dental Pulp Stem Cell Senescence: A Potential Strategy for Improving Regenerative Endodontic Procedures.
Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
3 authors.
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Abstract
The effects of aging on dental pulp stem cells (DPSCs) have been extensively investigated in recent years. Senescent DPSCs may negatively affect pulpal regeneration in the aged tooth and be a driver of chronic inflammation. In the near future, targeting key inducers of cellular senescence may therefore become central to the development of new strategies to enhance the regenerative capacities of DPSCs. The aim of this perspective article is to provide an overview of the molecular mechanisms driving cellular senescence in DPSCs. Furthermore, potential clinical applications of targeting DPSC senescence in regenerative endodontics are discussed, including strategies to preserve exposed pulp, promote pulp-like tissue through revascularization or revitalization, and achieve complete pulp regeneration.
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Registered trials
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