ArticleBioengineering (Basel, Switzerland)2026
Mechanotherapeutic Modulation of the Nasal Microenvironment: RAMPA-Induced Maxillofacial Remodeling and Its Pathophysiological Impact on Mucus Rheology and Chronic Inflammation.
Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPediatric maxillary deficiency often leads to upper airway constriction and chronic sinonasal inflammation. While conventional expansion focuses on dental width, the Right Angle Maxillary Protraction Appliance (RAMPA) system targets three-dimensional skeletal remodeling. This study investigates the mechanotherapeutic impact of RAMPA on the nasal microenvironment, specifically focusing on bone remodeling triggers and mucus rheology.
methodsPre- and post-treatment CBCT data from 20 pediatric patients were analyzed. Computational Fluid Dynamics (CFD) and Finite Element Analysis (FEA) were employed to evaluate mechanical strain patterns and aerodynamic changes. We specifically identified the "BMP-2 TRIGGER ZONE" where tensile stress induces osteogenic signaling. Mucus clearance efficiency was modeled using the Carreau-Yasuda rheological framework.
resultsRAMPA treatment resulted in a 61.2% mean increase in sinonasal volume (
conclusionsOur findings suggest that RAMPA-induced remodeling acts as a mechanotherapeutic modulator. As a proof-of-concept study, by triggering molecular signaling for bone formation and restoring sinonasal homeostasis through improved aerodynamics, this intervention may provide a comprehensive solution for chronic sinonasal inflammation beyond simple mechanical expansion.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.