Evidence map›Paper›PMID 42351855›Full record

ArticleBioengineering (Basel, Switzerland)2026

The Use of Osteo-Inductive 3D-Printed Scaffolds Covered with a Pleiotrophin Peptide for Bone Defects: An In Vivo Experimental Study.

Dimitrios Tsoumanis, Emilios E Pakos, Ioannis Gkiatas, Ioannis Gelalis, Anna Batistatou, Evangelia Lampri, Despoina Deligianni, Evangelia Papadimitriou, Dimitrios Fotiadis, Anastasios Korompilias

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioengineering (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Dimitrios TsoumanisDepartment of Orthopaedics, University Hospital of Ioannina, 45110 Ioannina, Greece.
Emilios E PakosDepartment of Orthopaedics, University Hospital of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-0018-4204
Ioannis GkiatasDepartment of Orthopaedics, University Hospital of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0003-2541-5467
Ioannis GelalisDepartment of Orthopaedics, University Hospital of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-1918-9478
Anna BatistatouPathological Anatomy, University Hospital of Ioannina, 45110 Ioannina, Greece.
Evangelia LampriPathological Anatomy, University Hospital of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-8633-7135
Despoina DeligianniDepartment of Mechanical Engineering and Aeronautics, University of Patras, 26504 Patras, Greece.
Evangelia PapadimitriouDepartment of Pharmacy, University of Patras, 26504 Patras, Greece.ORCID 0000-0001-6429-4325
Dimitrios FotiadisUnit of Medical Technology and Intelligent Information Systems, University of Ioannina, 45110 Ioannina, Greece.ORCID 0000-0002-7362-5082
Anastasios KorompiliasDepartment of Orthopaedics, University Hospital of Ioannina, 45110 Ioannina, Greece.

Funding

European Regional Development Fund of the European Union and Greek national funds through the Operational Program Competitiveness, Entrepreneurship, and Innovation, under the call RESEARCH - CREATE - INNOVATE T2EDK-03681
6 · The paper itself

Abstract

The present study investigated the effect of a 3D-printed nanocomposite scaffold on bone healing in vivo. The scaffolds used were made from the bioresorbable thermoplastic polycaprolactone polymer, blended with Multi-Walled Carbon Nanotubes functionalized with chitosan, and manufactured with a rectilinear infill pattern and interconnected pores of 500 μm in size. The study included three groups of 10 Wistar rats, in which a 2 mm bone defect was created in the middle of the right femur. In the scaffold/peptide group, the gap was filled with the scaffold loaded with a peptide corresponding to human pleiotrophin amino acids 48-56 (PTN

Indexed as

angiogenesisbone defectsbone healingosteoinductionscaffolds

Identifiers

PMID42351855
PMCPMC13295993

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.