Evidence map›Paper›PMID 42351822›Full record

ReviewBiomedicines2026

Surgical Rodent Models for the Study of Peripheral Arterial Disease.

Lauren Carmon, Kristopher Maier, Vivian Gahtan

Abstract readReview
In one paragraph

Review in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Lauren CarmonDepartment of Surgery, Loyola University of Chicago, Maywood, IL 60153, USA.ORCID 0009-0007-2962-6663
Kristopher MaierDepartment of Surgery, Loyola University of Chicago, Maywood, IL 60153, USA.ORCID 0000-0003-0987-4751
Vivian GahtanDepartment of Surgery, Loyola University of Chicago, Maywood, IL 60153, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiovascular disease remains the leading cause of morbidity and mortality worldwide, with atherosclerosis and maladaptive vascular remodeling serving as central drivers of clinical events. Mechanistic investigation of arterial disease processes relies heavily on experimental animal models that permit precise control of vascular injury, hemodynamic forces, and ischemic stress. Over the past several decades, murine and rat models have become indispensable tools for studying endothelial dysfunction, intimal hyperplasia, flow-mediated remodeling, and ischemia-reperfusion injury. Each model reproduces distinct aspects of human vascular pathology while offering unique technical and biological advantages. This review summarizes commonly used murine and rat models of arterial disease, emphasizing the biological mechanisms they study, the surgical techniques used, pathophysiology, experimental endpoints, advantages, and limitations.

Indexed as

angiogenesisarterial injuryarteriogenesisintimal hyperplasiaischemia–reperfusionneointimal hyperplasia

Identifiers

PMID42351822
PMCPMC13296514

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.