A Novel Technology Platform for Extracellular Vesicle-Targeted Expression of Drug-Metabolizing Enzymes: Driving CYP3A4 Expression and Secretion via the EABR Motif.

Haihong Hu, Shaojun Zhou, Yi Peng, Yuru Liu, Zhiyuan Qin, Lushan Yu, Su Zeng

Abstract read

In one paragraph

Article in Biomedicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Haihong HuZhejiang Province Key Laboratory of Anti-Cancer Drug Research, State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Drug Metabolism and Pharmaceutical Analysis, Research Center for Clinical Pharmacy, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Shaojun ZhouZhejiang Province Key Laboratory of Anti-Cancer Drug Research, State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Drug Metabolism and Pharmaceutical Analysis, Research Center for Clinical Pharmacy, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Yi PengZhejiang Province Key Laboratory of Anti-Cancer Drug Research, State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Drug Metabolism and Pharmaceutical Analysis, Research Center for Clinical Pharmacy, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Yuru LiuZhejiang Province Key Laboratory of Anti-Cancer Drug Research, State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Drug Metabolism and Pharmaceutical Analysis, Research Center for Clinical Pharmacy, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.

Zhiyuan QinDepartment of Biology, School of Arts & Sciences, University of Pennsylvania, Philadelphia, PA 19104, USA.

Lushan YuZhejiang Province Key Laboratory of Anti-Cancer Drug Research, State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Drug Metabolism and Pharmaceutical Analysis, Research Center for Clinical Pharmacy, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0003-1467-2126

Su ZengZhejiang Province Key Laboratory of Anti-Cancer Drug Research, State Key Laboratory of Advanced Drug Delivery and Release Systems, Institute of Drug Metabolism and Pharmaceutical Analysis, Research Center for Clinical Pharmacy, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-1418-6825

Funding

Zhejiang Provincial Natural Science Foundation LJHSD26H310001

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

CEP55-EABRCytochrome P450 3A4ESCRT pathwayextracellular vesicles

Identifiers

PMID42351727

DOI10.3390/biomedicines14061299

PMCPMC13296741

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.