Evidence map›Paper›PMID 42351426›Full record

ArticleDiagnostics (Basel, Switzerland)2026

Hypertrophic Versus Atrophic Photoaging in Monozygotic Twins: Insights from a Unique Vitiligo Case Report.

Ilaria Proietti, Vincenzo Coppolelli, Alberto Taliano, Annunziata Dattola, Steven Paul Nisticò, Giovanni Pellacani, Concetta Potenza, Stefania Guida

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ilaria ProiettiDermatology Unit "Daniele Innocenzi", "A. Fiorini" Hospital, 04019 Terracina, Italy.ORCID 0000-0003-3795-3190
Vincenzo CoppolelliDermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, 00161 Rome, Italy.ORCID 0009-0001-8346-8359
Alberto TalianoDermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, 00161 Rome, Italy.ORCID 0009-0002-0811-7601
Annunziata DattolaDermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, 00161 Rome, Italy.
Steven Paul NisticòDermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, 00161 Rome, Italy.ORCID 0000-0002-3828-0883
Giovanni PellacaniDermatology Unit, Department of Clinical Internal, Anesthesiological and Cardiovascular Science, University of La Sapienza, 00161 Rome, Italy.ORCID 0000-0002-7222-2951
Concetta PotenzaDermatology Unit "Daniele Innocenzi", "A. Fiorini" Hospital, 04019 Terracina, Italy.
Stefania GuidaUnit of Dermatology, IRCCS Ospedale San Raffaele, 20132 Milano, Italy.ORCID 0000-0002-8221-6694

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This report describes a case of 62-year-old monozygotic twin sisters showing markedly different patterns of cutaneous aging despite identical genetics. One twin, affected by long-standing non-segmental vitiligo, exhibited features of hypertrophic photoaging, including pronounced wrinkling and dermal thickening, while the unaffected twin showed an atrophic phenotype with smoother, thinner skin. Imaging findings supported these differences. The case highlights the complex interplay between ultraviolet exposure, genetic factors such as MC1R, and non-genetic influences, suggesting that melanocytic loss and environmental factors contribute significantly to divergent skin aging outcomes.

Indexed as

monozygotic twinsphotoagingUV exposurevitiligo

Identifiers

PMID42351426
PMCPMC13298552

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.