Evidence map›Paper›PMID 42351398›Full record

ArticleChirality2026

AQbD-Guided Chiral HPLC for Enantiomeric Impurity Analysis of Suzetrigine.

Sultanah M N Alhunayhin, Ayman M Algohary, Saja A Althobaiti, Abdullah H Alluhayb, Mona I Shahin, Ahmed M Ibrahim, Tamer H A Hasanin

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chirality, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sultanah M N AlhunayhinDepartment of Chemistry, College of Science Al-Zulfi, Majmaah University, Al-Majmaah, Saudi Arabia.
Ayman M AlgoharyDepartment of Chemistry, College of Science Al-Zulfi, Majmaah University, Al-Majmaah, Saudi Arabia.ORCID https://orcid.org/0000-0002-3057-3016
Saja A AlthobaitiDepartment of Chemistry, College of Science and Humanities in Al-Kharj, Prince Sattam Bin Abdulaziz University, Al-Kharj, Saudi Arabia.
Abdullah H AlluhaybDepartment of Chemistry, College of Science, Qassim University, Buraidah, Saudi Arabia.ORCID https://orcid.org/0009-0001-2591-0946
Mona I ShahinBiology Department, Faculty of Tymaa, Tabuk University, Tabuk, Saudi Arabia.
Ahmed M IbrahimEgyptian Drug Authority (EDA), Giza, Egypt.ORCID https://orcid.org/0000-0003-1095-1072
Tamer H A HasaninDepartment of Chemistry, Faculty of Science, Minia University, El-Minia, Egypt.ORCID https://orcid.org/0000-0002-2985-4208

Funding

Majmaah University
6 · The paper itself

Abstract

Suzetrigine (SUZ), an analgesic for acute pain, requires strict enantiomeric purity control. This study develops a robust chiral HPLC method for SUZ and its R-enantiomer using analytical quality by design (AQbD). Separation was achieved on a Chiralpak IC-3 column with an isocratic n-hexane-ethanol (90:10, v/v) mobile phase. The optimized method provided baseline resolution (R

Indexed as

Drug ContaminationAmidesAminopyridinesChromatography, High Pressure LiquidFuransStereoisomerismAmidesAminopyridinesFuranssuzetrigineaccuracy profileenantiomeric impuritygreen analytical chemistry

Identifiers

PMID42351398
PMCPMC13357262

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.