Evidence map›Paper›PMID 42351355›Full record

ArticlePest management science2026

Discovery of natural product-derived pesticide candidates: synthesis, aphicidal activity, and toxicological evaluation of andrographolide derivatives.

Wen Zhang, Xiao-Xia Song, Wen-Hui Zhang, Xin-Rui Zhou, Wei Yuan, Ji Zhang, Wei-Bao Kong, Jun-Yu Liang, Fei Wu

Abstract read
In one paragraph

Article in Pest management science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wen ZhangCollege of Life Sciences, Northwest Normal University, Lanzhou, China.ORCID https://orcid.org/0000-0003-3569-0251
Xiao-Xia SongCollege of Life Sciences, Northwest Normal University, Lanzhou, China.
Wen-Hui ZhangCollege of Life Sciences, Northwest Normal University, Lanzhou, China.
Xin-Rui ZhouCollege of Life Sciences, Northwest Normal University, Lanzhou, China.
Wei YuanDepartment of Neurology, Lanzhou University Second Hospital, Lanzhou, China.
Ji ZhangCollege of Life Sciences, Northwest Normal University, Lanzhou, China.
Wei-Bao KongCollege of Life Sciences, Northwest Normal University, Lanzhou, China.
Jun-Yu LiangCollege of Life Sciences, Northwest Normal University, Lanzhou, China.
Fei WuCollege of Life Sciences, Northwest Normal University, Lanzhou, China.

Funding

Gansu Province Education Science and Technology Innovation Project 2026A-007Natural Science Foundation of Gansu Province 25JRRA021Natural Science Foundation of Gansu Province 25JRRA612
6 · The paper itself

Abstract

backgroundTo address pest resistance, environmental concerns, and non-target toxicity associated with conventional pesticides, the natural product andrographolide was structurally optimized for the development of eco-friendly insecticides.

resultsA series of andrographolide derivatives were designed and synthesized, among which compound 9i exhibited the strongest insecticidal activity against Myzus persicae Sulzer, with an LC

conclusionStructural optimization substantially enhances the insecticidal activity of andrographolide. Compound 9i represents a promising lead candidate for eco-friendly insecticide development and provides a valuable basis for future pesticide discovery. © 2026 Society of Chemical Industry.

Indexed as

AphidsBiological ProductsDiterpenesInsecticidesAnimalsLarvaStructure-Activity RelationshipZebrafishandrographolideBiological ProductsDiterpenesInsecticidesandrographolidenatural productspesticidal activitiesstructural modificationsstructure–activity relationship

Identifiers

PMID42351355
PMCPMC13569365

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.