Evidence map›Paper›PMID 42351323›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

An siENPP1-Delivering Bimetallic MOF Nanocomplex Enables Triple Activation of the cGAS-STING Pathway for Synergistic Triple-Negative Breast Cancer Therapy.

Shi Chen, Mengjia Shi, Yi Chen, Yong Wang, Yi Li, Dayong Yang, Jinhong Guo, Cuiping Mao

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In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Shi ChenCollege of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), Chongqing Medical University, Chongqing, P. R. China.ORCID https://orcid.org/0009-0003-9920-0247
Mengjia ShiThe Center for Clinical Molecular Medical Detection, Innovative and Translational Laboratory of Molecular Diagnostics, Laboratory Medicine Center, The First Affiliated Hospital, Chongqing Medical University, Chongqing, P. R. China.
Yi ChenCollege of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), Chongqing Medical University, Chongqing, P. R. China.
Yong WangCollege of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), Chongqing Medical University, Chongqing, P. R. China.
Yi LiCollege of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), Chongqing Medical University, Chongqing, P. R. China.ORCID https://orcid.org/0000-0003-2226-5918
Dayong YangDepartment of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai, P. R. China.
Jinhong GuoCollege of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), Chongqing Medical University, Chongqing, P. R. China.
Cuiping MaoCollege of Laboratory Medicine, Key Laboratory of Clinical Laboratory Diagnostics (Ministry of Education), Chongqing Medical University, Chongqing, P. R. China.

Funding

Brain-Gain Plan of New Chongqing Young Elite Program CSTB2024YCJH-KYXM0056National Key R&D Program of China 2023YFF0724300National Natural Science Foundation of China 82502844Natural Science Foundation of Chongqing Municipality CSTB2024NSCQ-MSX0343Natural Science Foundation of Chongqing Outstanding Youth Science Fund CSTB2024NSCQ-JQX0012Scientific and Technological Research Program of Chongqing Municipal Education Commission KJQN202400453Sichuan-Chongqing Joint Technology Innovation and Application Development Fund 2024TIAD-CYKJCXX0038
6 · The paper itself

Abstract

Triple-negative breast cancer (TNBC) is associated with poor prognosis due to its highly heterogeneous tumor immune microenvironment and the lack of actionable molecular targets, which collectively limit the efficacy of current therapies. To address these challenges, PEI/siENPP1@Mn-ZIF-8 (PEMZ) is reported, an integrated gene-chemodynamic-immune nanocomplex that activates the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway through a previously unattainable triple-activation mechanism. PEMZ efficiently encapsulates siENPP1, protects it from degradation, and enables acid-responsive cytosolic release, resulting in sustained ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) silencing and accumulation of tumor-derived cyclic 2',3'-GMP-AMP (cGAMP). Simultaneously, the Mn

Indexed as

Membrane ProteinsNucleotidyltransferasesTriple Negative Breast NeoplasmsAnimalsCell Line, TumorcGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseFemaleHumansMiceNucleotides, CyclicSTING Proteincyclic guanosine monophosphate-adenosine monophosphateCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNucleotides, CyclicNucleotidyltransferasesSTING1 protein, humanSTING ProteincGAS‐STINGENPP1metal–organic frameworksnucleic acid deliverysynergistic therapy

Identifiers

PMID42351323
PMCPMC13431937

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.