Evidence map›Paper›PMID 42351292›Full record

Observational studyRetina (Philadelphia, Pa.)2026

PERSISTENT PLACOID MACULOPATHY: Long-term Outcomes and Prognostic Factors.

Claire Seppey, Eirini Kaisari, Mickael Anjou, Chiara M Eandi, Aude Ambresin, Antoine P Brézin, Yan Guex-Crosier, Florence Hoogewoud

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Retina (Philadelphia, Pa.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Claire SeppeyDepartment of Ophthalmology, Fondation Asile des Aveugles, Hôpital Ophtalmique Jules-Gonin, Université de Lausanne, Lausanne, Switzerland.
Eirini KaisariDepartment of Ophthalmology, Fondation Asile des Aveugles, Hôpital Ophtalmique Jules-Gonin, Université de Lausanne, Lausanne, Switzerland.
Mickael AnjouOphtalmopôle de Paris, Hôpital Cochin, Department of Ophthalmology, Université Paris Descartes, Paris, France.
Chiara M EandiDepartment of Ophthalmology, Fondation Asile des Aveugles, Hôpital Ophtalmique Jules-Gonin, Université de Lausanne, Lausanne, Switzerland.
Aude AmbresinSwiss Visio Retina Research Center, Swiss Visio Montchoisi, Lausanne, Switzerland.
Antoine P BrézinOphtalmopôle de Paris, Hôpital Cochin, Department of Ophthalmology, Université Paris Descartes, Paris, France.
Yan Guex-CrosierDepartment of Ophthalmology, Fondation Asile des Aveugles, Hôpital Ophtalmique Jules-Gonin, Université de Lausanne, Lausanne, Switzerland.
Florence HoogewoudDepartment of Ophthalmology, Fondation Asile des Aveugles, Hôpital Ophtalmique Jules-Gonin, Université de Lausanne, Lausanne, Switzerland.ORCID 0000-0003-2521-1333

Funding

AURIS Foundation NAthe Blatter Family grant NAthe Fleurette Wagemakers Foundation NAthe Ingvar Kamprad Fund NAthe Kononchuk Family grant NAthe W. & E. Grand d'Hauteville Foundation NA
6 · The paper itself

Abstract

purposeTo evaluate the long-term visual outcomes, recurrence, complication rate, and systemic associations of persistent placoid maculopathy. We also aimed to identify predictors of final visual acuity.

methodsThis study combined a retrospective multicenter case series from three tertiary referral centers with a systematic review of the literature. Inclusion criteria were bilateral placoid macular lesions with characteristic multimodal imaging findings and a minimum follow-up of 23 months. Visual acuity, systemic associations, complications, recurrence, and treatments were assessed.

resultsTwenty-three patients (46 eyes) were included, six patients from our centers and 17 patients from the literature. The median follow-up was 3.75 years. Severe visual loss (<20/100) at final follow-up was observed in one third of eyes. Choroidal neovascularization occurred in 65.2% of eyes and recurrence in 21.7%. Systemic cardiovascular comorbidities were common (87.5%), and two patients presented cerebral vasculitis. Systemic treatment was significantly associated with better final visual acuity ( P = 0.014).

conclusionPersistent placoid maculopathy presents a high complication rate and poor visual prognosis. Systemic treatment was significantly associated with better final visual acuity in our study.

Indexed as

Fluorescein AngiographyMacula LuteaVisual AcuityAdultAgedFemaleFollow-Up StudiesFundus OculiHumansMaleMiddle AgedPrognosisRecurrenceRetrospective StudiesTime FactorsTomography, Optical Coherenceacute posterior multifocal placoid pigment epitheliopathychorioretinitischoroidal neovascularizationmacular atrophymultimodal imagingpersistent placoid maculopathyplacoid lesionstreatmentuveitisvisual prognosiswhite dots syndrome

Identifiers

PMID42351292
PMCPMC13596190

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.