ArticleAnnals of clinical and translational neurology2026
Integrating Time-Adjusted Imaging Instability Into Functional Outcome Prediction After Intracerebral Hemorrhage: Development and Validation of the HAGIV Score.
Article in Annals of clinical and translational neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
Abstract
objectiveEarly risk stratification may support clinical decision-making in spontaneous intracerebral hemorrhage (ICH). We aimed to develop and internally validate HAGIV, a score integrating frequency of imaging markers (FIM), a time-adjusted non-contrast computed tomography (CT) metric of hematoma expansion, with established predictors for 90-day functional outcome in supratentorial ICH.
methodsThis prespecified prognostic modeling study used a multicenter retrospective cohort of consecutive supratentorial ICH patients with baseline non-contrast CT within 6 h of onset (January 2018-August 2022). The HAGIV score was constructed by assigning integer points according to regression coefficients from multivariable logistic regression. Discrimination for poor functional outcome (modified Rankin Scale score 3-6) was assessed using area under the curve (AUC) and compared with established ICH prognostic scores.
resultsHAGIV incorporated baseline hematoma volume (H), age (A), Glasgow Coma Scale score (G), frequency of imaging markers (I), and presence of intraventricular hemorrhage (V). In the derivation cohort, HAGIV achieved an AUC of 0.86, significantly outperforming the ICH (0.81), MICH (0.81), Outcome (0.72), and Landseed ICH (0.79) scores (all p < 0.001, DeLong's test). This superiority was confirmed in the validation cohort, where HAGIV maintained an AUC of 0.84 compared with 0.76, 0.78, 0.75, and 0.75, respectively.
interpretationIn this predominantly small-to-moderate, supratentorial ICH cohort, HAGIV integrated FIM with established prognostic variables and improved discrimination for 90-day outcome. It may support interpretable early risk stratification for counseling and trial design, but prospective external validation is required before broader clinical implementation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.