Evidence map›Paper›PMID 42351253›Full record

SynthesisJournal of cardiothoracic surgery2026

T2-sparing vs T2-including sympathectomy for hyperhidrosis: a meta-analysis on compensatory sweating.

Lucas Monteiro Delgado, Paula Duarte D'Ambrosio, Rachid Eduardo Noleto da Nobrega Oliveira, Keith Mortman, Túlio Caldonazo, Felipe S Passos, Marcelo Albuquerque Barbosa Martins, Deepti Sreepathi, Adriana-Simoneta Pimienta-Ibarra, Paulo Manuel-Pêgo Fernandes and 2 more

Abstract readMeta-AnalysisReview
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In one paragraph

Synthesis in Journal of cardiothoracic surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Lucas Monteiro DelgadoFederal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Paula Duarte D'AmbrosioDepartment of Thoracic Surgery, Faculdade de Medicina, Hospital das Clinicas de Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil.
Rachid Eduardo Noleto da Nobrega OliveiraDepartment of Thoracic Surgery, Barretos Cancer Center, São Paulo, Brazil.
Keith MortmanDivision of Thoracic Surgery, The George Washington University, Washington, D.C., USA.
Túlio CaldonazoDepartment of Cardiothoracic Surgery, Jena University Hospital, Am Klinikum 1, 07747, Jena, Germany. tulio.caldonazo@med.uni-jena.de.
Felipe S PassosDepartment of Thoracic Surgery, MaterDei Hospital, Salvador, Brazil.
Marcelo Albuquerque Barbosa MartinsFederal University Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
Deepti SreepathiIndependent Scholar, Boston, MA, USA.
Adriana-Simoneta Pimienta-IbarraDepartment of Thoracic Surgery, Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas, Mexico City, Mexico.
Paulo Manuel-Pêgo FernandesDepartment of Thoracic Surgery, Faculdade de Medicina, Hospital das Clinicas de Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil.
Nelson WoloskerDepartment of Health Sciences, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.
José Ribas Milanez CamposDepartment of Thoracic Surgery, Faculdade de Medicina, Hospital das Clinicas de Sao Paulo, Universidade de Sao Paulo, Sao Paulo, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSympathectomy is the definitive treatment for primary hyperhidrosis, offering high success rates. However, compensatory sweating (CS) remains a frequent and distressing complication. The level of ganglionic resection, particularly the inclusion of T2, may influence CS incidence, but evidence remains inconsistent.

methodsA systematic search of PubMed, Embase, and the Cochrane Library was conducted up to July 2025, to identify studies comparing T2-sparing versus T2-including sympathectomy for primary hyperhidrosis. Pooled odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using random-effects models. Heterogeneity was assessed using the I2 statistic. For outcomes with significant heterogeneity, leave-one-out sensitivity analyses were performed.

resultsEleven studies involving 3,090 patients were included. Of these, 47.2% underwent T2-sparing sympathectomy and 52.8% underwent T2-including procedures. T2-sparing sympathectomy was associated with a significantly lower incidence of overall CS (OR 0.38; 95% CI 0.21-0.67; p = 0.0009; I2 = 65%) and severe CS (OR 0.43; 95% CI 0.28-0.64; p < 0.0001; I2 = 19%). Subgroup analyses confirmed consistent results across both randomized and non-randomized studies, as well as across short-term (≤ 12 months) and long-term (> 12 months) follow-up periods. Sensitivity analyses confirmed the robustness of the findings. No publication bias was detected.

conclusionsT2-sparing sympathectomy was associated with a significantly lower incidence of CS. These findings support avoiding T2 when feasible to minimize postoperative morbidity. Further prospective studies are needed to confirm these results.

Indexed as

HyperhidrosisSweatingSympathectomyHumansPostoperative ComplicationsThoracic VertebraeCompensatory sweatingEndoscopic thoracic sympathectomyHyperhidrosisMeta-analysis

Identifiers

PMID42351253
PMCPMC13307732

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.