Evidence map›Paper›PMID 42351249›Full record

ArticleCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions2026

Progression of Coronary Artery Disease in Patients Undergoing Transcatheter Aortic Valve Replacement: A Quantitative Coronary Angiography and Quantitative Flow Ratio Analysis.

Jason Galo, Abdullah Al Qaraghuli, Cheng Zhang, Gal Peleg, Kalyan R Chitturi, Yonathan Hasin, Idit Avrahami, Shaan A Ahmed, Pablo M Rubio, Abhishek Chaturvedi and 3 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jason GaloSection of Interventional Cardiology, MedStar Washington Hospital Center, Washington DC, USA.ORCID https://orcid.org/0000-0001-9036-7049
Abdullah Al QaraghuliDepartment of Internal Medicine, MedStar Washington Hospital Center, Washington DC, USA.
Cheng ZhangSection of Interventional Cardiology, MedStar Washington Hospital Center, Washington DC, USA.
Gal PelegDepartment of Internal Medicine, MedStar Washington Hospital Center, Washington DC, USA.
Kalyan R ChitturiSection of Interventional Cardiology, MedStar Washington Hospital Center, Washington DC, USA.
Yonathan HasinAriel University, Ariel, Israel.
Idit AvrahamiAriel University, Ariel, Israel.
Shaan A AhmedSection of Interventional Cardiology, MedStar Washington Hospital Center, Washington DC, USA.ORCID https://orcid.org/0000-0001-5344-7955
Pablo M RubioSection of Interventional Cardiology, MedStar Washington Hospital Center, Washington DC, USA.ORCID https://orcid.org/0000-0001-8674-1827
Abhishek ChaturvediSection of Interventional Cardiology, MedStar Washington Hospital Center, Washington DC, USA.ORCID https://orcid.org/0000-0003-0241-2845
Beni VermaSection of Interventional Cardiology, MedStar Washington Hospital Center, Washington DC, USA.
Itsik Ben-DorSection of Interventional Cardiology, MedStar Washington Hospital Center, Washington DC, USA.ORCID https://orcid.org/0009-0006-6026-9097
Ron WaksmanSection of Interventional Cardiology, MedStar Washington Hospital Center, Washington DC, USA.ORCID https://orcid.org/0000-0002-4063-9226

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe progression of coronary artery disease (CAD) following transcatheter aortic valve replacement (TAVR) is poorly understood. Changes in coronary hemodynamics after TAVR and their relationship with atherosclerosis remain an active area of investigation. Quantitative coronary angiography (QCA) and quantitative flow ratio (QFR) offer objective, reproducible assessments of coronary disease burden, hemodynamics, and progression.

aimsTo evaluate anatomic and hemodynamic progression of CAD in select patients undergoing TAVR using QCA and QFR, and to compare outcomes by valve type-self-expanding valves (SEV) versus balloon-expandable valves (BEV).

methodsA total of 92 patients who underwent TAVR and had both pre- and post-TAVR invasive coronary angiography (CA) were retrospectively analyzed. QCA and QFR analyses were performed on major coronary arteries. CAD progression was defined in 2 ways: (1) QCA diameter stenosis (DS) increase ≥ 10% or baseline < 50% and follow‑up ≥ 50%; (2) QFR decrease ≥ 0.05 or baseline QFR > 0.80 and follow-up ≤ 0.80. Clinical and echocardiographic data, statin use, and antiplatelet therapy were assessed longitudinally.

resultsOver a median follow-up of 756 days (IQR 254-1302), CAD progression in patients with clinically indicated post-TAVR CA was observed in 96.6% of patients using QCA and in 85.6% of patients using QFR. Among vessel subsegments, CAD progression by QCA was greatest in the LAD proximal and mid segments (60.99% and 58.46%, respectively), and lowest in distal LCX and distal RCA (37.63%, 39.04%, respectively). CAD progression by QFR was significantly greater in SEV when compared to BEV (1-year: 39.4% vs. 21.9%; 2-year: 47.4% vs. 39.3%, log rank p = 0.038). There was no statistically significant difference in the QCA-defined CAD progression between SEV and BEV, though a numerically higher progression was seen in SEV.

conclusionsMost TAVR recipients undergoing clinically indicated repeat CA demonstrate CAD progression on serial angiography. By QFR, progression is influenced by valve type, while by QCA and QFR, trended with baseline disease severity. Further investigation into coronary progression following TAVR is warranted.

Indexed as

Aortic ValveAortic Valve StenosisCoronary AngiographyCoronary Artery DiseaseCoronary CirculationCoronary VesselsHemodynamicsTranscatheter Aortic Valve ReplacementAgedAged, 80 and overBlood Flow VelocityCardiac CatheterizationDisease ProgressionFemaleHeart Valve ProsthesisHumanscoronary artery disease (CAD) progressioncoronary hemodynamicsquantitative coronary angiography (QCA)quantitative flow ratio (QFR)self‐expanding versus balloon‐expandable valvestranscatheter aortic valve replacement (TAVR)

Identifiers

PMID42351249
PMCPMC13532441

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.