Evidence map›Paper›PMID 42351244›Full record

ArticleJournal of animal science and biotechnology2026

A microbial consortium constructed with gut microbes of Chinese native chicken breeds protects chicks against Salmonella infection.

Yimei Feng, Meihong Zhang, Fengwenhui Zhang, Guanyu Hou, Jinxin Zhang, Shuran Zhao, Yuqing Feng, Dan Liu, Dahai Xu, Yongfei Hu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yimei FengSanya Institute, China Agricultural University, Sanya, 572025, Hainan, China.
Meihong ZhangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Fengwenhui ZhangSanya Institute, China Agricultural University, Sanya, 572025, Hainan, China.
Guanyu HouTropical Crops Genetic Resources Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou, 571101, Hainan, China.
Jinxin ZhangState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Shuran ZhaoState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Yuqing FengState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Dan LiuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Dahai XuState Key Laboratory of Animal Nutrition and Feeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China. 18615183951@163.com.
Yongfei HuSanya Institute, China Agricultural University, Sanya, 572025, Hainan, China. huyongfei@cau.edu.cn.

Funding

Hainan Provincial Natural Science Foundation of China 2021JJLH0084
6 · The paper itself

Abstract

backgroundThe gut microbiota plays a crucial role in protecting chickens against colonization by enteric pathogens, such as Salmonella. Native chickens, including Wenchang chicken and Danzhou chicken, harbor a highly diverse gut microbiota, which may contain anti-pathogenic strains. This study aimed to construct a microbial consortium from these native chicken breeds and evaluate its efficacy in protecting chicks from Salmonella infection.

resultsA collection of 273 bacterial strains, representing 61 species, was isolated from the cecal digesta of Wenchang chicken and Danzhou chicken. From this collection, 29 strains were identified as exhibiting in vitro inhibitory activity against the indicator pathogens. Genomic analysis of the constituent strains in consortium BL6 revealed the genetic potential for producing antimicrobial peptides and secondary metabolites, suggesting a mechanistic basis for the inhibition. In a chick model challenged with S. Typhimurium, BL6 mitigated intestinal damage by promoting crypt restoration, enhanced barrier function, and enriched Lactobacillus, collectively contributing to improved intestinal health.

conclusionsThese findings underscore the potential of a microbial consortium derived from the gut microbes of native chickens in combating Salmonella infection. This research offers valuable insights for developing innovative strategies to prevent and treat pathogen infections in broilers.

Indexed as

ChickGut microbiotaMicrobial consortiumSalmonella Typhimurium

Identifiers

PMID42351244
PMCPMC13307419

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.