Evidence map›Paper›PMID 42351221›Full record

ArticleReproductive biology and endocrinology : RB&E2026

Mice lacking NF-ĸB1 undergo premature ovarian aging.

Carolina Lliberos, Seng H Liew, Yasmin Lewis, Nadeen Zerafa, Darcy Ellis, Ashley Mansell, Steve Gerondakis, Karla Hutt

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproductive biology and endocrinology : RB&E, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Carolina LliberosDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Seng H LiewDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Yasmin LewisDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Nadeen ZerafaDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Darcy EllisDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Ashley MansellCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC, Australia.
Steve GerondakisDepartment of Biochemistry, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia.
Karla HuttDepartment of Anatomy and Developmental Biology, Monash Biomedicine Discovery Institute, Monash University, Clayton, VIC, Australia. karla.hutt@monash.edu.

Funding

Australian Research Council 190100265National Health and Medical Research Council 2027120
6 · The paper itself

Abstract

Female fertility declines dramatically with age, primarily due to the loss of oocyte number and quality. This physiological event leads to ovarian dysfunction and infertility, irregular cycles and ultimately menopause. Despite its significance, the factors that underlie the natural process of age-related follicle loss, or those that promote premature ovarian aging, remain unknown. Here we show that low levels of chronic inflammation in mice lacking the nuclear factor kappa B transcription factor NF-ĸB1 (Nfkb1

Indexed as

AgingAging, PrematureNF-kappa B p50 SubunitOvarian ReserveOvaryPrimary Ovarian InsufficiencyAnimalsFemaleFertilityInflammationMiceMice, Inbred C57BLMice, KnockoutOvarian FollicleNF-kappa B p50 SubunitNfkb1 protein, mouseAgingFollicleInflammationNF-ĸBOvaryPremature aging

Identifiers

PMID42351221
PMCPMC13556056

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.