Evidence map›Paper›PMID 42351035›Full record

ArticleBMC pulmonary medicine2026

Microbiome-host interactions in different pathomic subtypes of early-stage lung adenocarcinoma.

Tianshuai He, Zhu Ai, Qijia Han, Fang Chen, Hao Wang, Minyi Wu, Qiuxing Chen, Shulin Li, Lei Wang, Zhihe Yang and 3 more

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Article in BMC pulmonary medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Tianshuai HeDepartment of Radiology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.
Zhu AiDepartment of Radiology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.
Qijia HanDepartment of Radiology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.
Fang ChenDepartment of Pathology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.
Hao WangDepartment of Pathology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.
Minyi WuDepartment of Radiology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.
Qiuxing ChenDepartment of Radiology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.
Shulin LiDepartment of Radiology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.
Lei WangDepartment of Radiology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.
Zhihe YangDepartment of Radiology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.
Peng WangDepartment of Radiology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China.
Zhang WangSchool of Life Sciences, South China Normal University, Guangzhou, China. wangz@m.scnu.edu.cn.
Zhiming XiangDepartment of Radiology, The Affiliated Panyu Central Hospital, Guangzhou Medical University, Guangzhou, China. xiangzhiming@pyhospital.com.cn.

Funding

National Natural Science Foundation of China 82171931
6 · The paper itself

Abstract

backgroundMicrobiome-host interactions in different pathological subtypes of the early-stage lung adenocarcinoma (LUAD) remain poorly understood.

methodsWe conducted histopathological and imaging analysis on a cohort of 106 Chinese patients with LUAD. Further deep analysis of the lung tissue microbiome, serum metabolome, and host transcriptome was performed. Using correlation analysis, microbial genetic information, and established metabolite-human gene pairs, we integrated multi-omics data to explore potential associations between the microbiome, microbial metabolites, and host gene expression.

findingsWe identified distinct groups based on malignancy severity. Massilia, Sphingomonas, Staphylococcus, and Brevundimonas may influence host gene expression through their metabolites, affecting the progression of LUAD. We used Mendelian Randomization(MR) and found suggestive evidence that the levels of key metabolites (serotonin, uric acid) are negatively associated with LUAD risk. INTERPRETATIONS: This study demonstrates that pathological images of early-stage LUAD cells can reflect potential clinical differences, and some microbial-metabolite-gene potential associations have been found in early-stage LUAD, which may affect the development of early-stage lung adenocarcinoma.

fundingThis research was supported by grants from the National Natural Science Foundation of China (No. 82171931), the Guangdong Basic and Applied Basic Research Foundation Enterprise Joint Fund (2025).

Indexed as

Adenocarcinoma of LungLung NeoplasmsMicrobiotaAgedChinaFemaleHumansMaleMetabolomeMiddle AgedMultiomicsNeoplasm StagingTranscriptomeLung adenocarcinomaMendelian randomizationMulti omicsPathomics

Identifiers

PMID42351035
PMCPMC13555953

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