Evidence map›Paper›PMID 42351024›Full record

ArticleBMC neurology2026

Adenylate kinase 5 autoimmune encephalitis following craniopharyngioma radiotherapy.

Moyuan Quan, Fuyun Ren, Tengfei Sun, Xiaojing Chang, Liping Chen, Liang Wang

Abstract readCase Reports
In one paragraph

Article in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Moyuan QuanDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Fuyun RenDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Tengfei SunHebei Medical University, Shijiazhuang, Hebei, China.
Xiaojing ChangDepartment of Radiotherapy, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Liping ChenDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. chenliping301@163.com.
Liang WangDepartment of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China. wangliang@hebmu.edu.cn.

Funding

the Natural Science Foundation of Hebei Province H2022206162
6 · The paper itself

Abstract

backgroundAnti-AK5 encephalitis is a rare, non-paraneoplastic autoimmune disorder, typically characterized by anterograde amnesia as a core clinical manifestation. Although seizures are infrequent in the early disease phase, some patients may develop seizures as the condition progresses. CASE PRESENTATION: We report a rare case of anti-adenylate kinase 5 (AK5) autoimmune encephalitis following surgical resection and radiotherapy for craniopharyngioma. After cranial radiotherapy, the patient exhibited clinical manifestations such as personality changes and a decline in recent memory. However, the diagnosis was not made until several years later when the patient presented with the onset of epilepsy. By that time, imaging already showed abnormal signals and atrophy in the hippocampus.

conclusionThis case highlights the distinct clinical features of AK5 encephalitis and raises the potential association between brain radiotherapy and the development of autoimmune inflammation within the central nervous system.

Indexed as

Adenylate KinaseCraniopharyngiomaEncephalitisHashimoto DiseasePituitary NeoplasmsFemaleHumansMaleAdenylate Kinaseadenylate kinase 5Anti–adenylate kinase 5 (AK5)Autoimmune encephalitisRadiotherapy

Identifiers

PMID42351024
PMCPMC13555934

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.