ArticleJournal of racial and ethnic health disparities2026
Experiences of Discrimination and DNA Methylation Among Black Nulliparous Women.
Article in Journal of racial and ethnic health disparities, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Exposure to racial discrimination is a well-documented risk factor for adverse pregnancy outcomes. It is hypothesized that this association occurs through epigenetic changes. Researchers have identified associations between perceived discrimination and methylation of stress-response genes among racially and ethnically minoritized women. However, findings are limited by small sample sizes and inclusion of women who are several years postpartum. Little is known about the influence of discrimination on DNA methylation among Black women in pregnancy. Therefore, we conducted an epigenome-wide association study of 897 Black pregnant women who participated in the Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be (nuMoM2b) study to examine associations between experiences of racial discrimination and DNA methylation. Racial discrimination was measured using responses to the Experiences of Discrimination scale (range 0-9) completed in the second trimester of pregnancy. We dichotomized responses into low discrimination (0-2) and high discrimination (≥ 3) categories. Whole blood was collected in the first trimester of pregnancy and used for DNA extraction. We identified 130 CpG sites significantly associated with high levels of racial discrimination. There were 17 genes mapped to the 20 most significant CpG sites. Fourteen of those genes have disease-associated phenotypes including cancer (LCMT2, LINC02753, RARA, HSP90AA1, SMTN, LPCAT1, SPAG4, DAPK1, ZNF500), cardiomyopathy (SMTN), ovarian insufficiency (DMRT3), neurodevelopmental disability (MLPH, CDC123, OGFOD3), and asthma (STAT6). We identified novel associations between racial discrimination and disease-related genes among Black nulliparous pregnant women. Future research should include structural racism measures and study epigenetic pathways between racism and adverse pregnancy and birth outcomes.
Indexed as
Identifiers
42350862What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.