Evidence map›Paper›PMID 42350857›Full record

ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2026

Probiotic-associated Bacillus subtilis subsp. subtilis catheter-related bloodstream infection in a preterm infant: a caution for neonatal intensive care units.

Jiajia Chen, Xuelan Liu, Xiang Huang, Manzhi Huang

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Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiajia ChenDepartment of Clinical Pharmacy, Jieyang People's Hospital, Jieyang, Guangdong, China.
Xuelan LiuDepartment of Neonatology, Jieyang People's Hospital, Jieyang, Guangdong, China.
Xiang HuangDepartment of Neonatology, Jieyang People's Hospital, Jieyang, Guangdong, China.
Manzhi HuangDepartment of Clinical Pharmacy, Jieyang People's Hospital, Jieyang, Guangdong, China. manzhi_h@163.com.ORCID http://orcid.org/0009-0002-6465-0232

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the case of catheter-related bloodstream infection (CRBSI) potentially associated with probiotic administration of Bacillus subtilis subsp. subtilis. A 32⁺⁵-week preterm infant developed systemic inflammation during oral probiotic therapy. CRBSI was definitively diagnosed via differential time to positivity between peripheral and catheter-drawn blood cultures. Microbiological analysis demonstrated that clinical isolates and the probiotic strain shared identical antimicrobial susceptibility profiles; however, this is not definitive proof of strain identity. This novel case suggests a potential infectious risk for B. subtilis in neonates with central venous access and underscores the necessity of considering probiotics as a potential source of catheter-related sepsis.

Indexed as

Bacillus subtilis subsp. subtilisCatheter-related bloodstream infectionPreterm infantProbiotics

Identifiers

PMID42350857

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.