Evidence map›Paper›PMID 42350833›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Mapping integrated care for brain tumour-related epilepsy in the Italian RIN-IRCCS network.

Elena Anghileri, Alessia Marcassoli, Veronica Villani, Giuseppe Didato, Claudia Milanaccio, Elena Pasini, Elisa Bennicelli, Pasquale Persico, Paola Bini, Giulia Berzero and 10 more

Abstract readMulticenter Study
In one paragraph

Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Elena Anghileri *Neuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta (FINCB), full member of the European Reference Network EURACAN, Milan, 20133, Italy. elena.anghileri@istituto-besta.it.ORCID http://orcid.org/0000-0001-7383-3108
Alessia Marcassoli *Neurology, Public Health and Disability Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, 20133, Italy.
Veronica VillaniNeuro-Oncology Unit, IRCCS Regina Elena National Cancer Institute, Rome, 00144, Italy.
Giuseppe DidatoEpilepsy Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, full member of the European Reference Network EpiCARE, Milan, 20133, Italy.
Claudia MilanaccioNeuro-Oncology Unit, IRCCS Istituto Giannina Gaslini, Genoa, 16147, Italy.
Elena PasiniNeurology Unit, IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, 40139, Italy.
Elisa BennicelliMedical Oncology Unit 2, IRCCS Ospedale Policlinico San Martino, Genoa, 16132, Italy.
Pasquale PersicoHematology and Medical Oncology Unit, IRCCS Humanitas Research Hospital, Rozzano, 20089, Italy.
Paola BiniNeurooncology Unit, IRCCS Mondino Foundation, Pavia, 27100, Italy.
Giulia BerzeroNeurology Unit, IRCCS Ospedale San Raffaele, Milan, 20132, Italy.
Angela MastronuzziNeuro-Oncology Unit, Bambino Gesù Children's Hospital, IRCCS, Rome, 00165, Italy.
Massimo FilippiNeuroimaging Research UnitNeurology UnitNeurorehabilitation Unit, and Neurophysiology Service, IRCCS Ospedale San Raffaele, Vita-Salute San Raffaele University, Milan, 20132, Italy.
Luca De PalmaNeurology, Epilepsy and Movement Disorders Unit, Bambino Gesù Children's Hospital, IRCCS, Full Member of European Reference Network on Rare and Complex Epilepsies, EpiCARE, Rome, 00165, Italy.
Giorgio ArcaraIRCCS San Camillo Hospital, Venice, Italy.
Anna BelliniNeurology Unit and Neurophysiology Service - IRCCS Ospedale San Raffaele, Milan, 20132, Italy.
Marta MaschioNeuro-Oncology Unit, IRCCS Regina Elena National Cancer Institute, Rome, 00144, Italy.
Andrea PaceNeuro-Oncology Unit, IRCCS Regina Elena National Cancer Institute, Rome, 00144, Italy.
Mariangela FarinottiNeuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta (FINCB), full member of the European Reference Network EURACAN, Milan, 20133, Italy.
Antonio SilvaniNeuro-Oncology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta (FINCB), full member of the European Reference Network EURACAN, Milan, 20133, Italy.
National Virtual Institute of Italian Network of Neuroscience

Funding

Ministero della Salute RRC
6 · The paper itself

Abstract

backgroundBrain tumour-related epilepsy is a frequent and disabling complication of primary and metastatic brain tumours, requiring multidimensional and coordinated management. However, specific guidelines and standardized care pathways for this condition are still lacking. This study aimed to assess the current organization of care for brain tumour-related epilepsy within the Italian Network of Neuroscience and Neuro-rehabilitation Research Institutes.

methodsA national, multicentre survey was conducted across participating centres between April and June 2024, with follow-up validation in December 2025. The questionnaire investigated human resources, technological availability, clinical pathways, and management strategies. Data were analysed descriptively.

resultsTen centres participated. All reported adopting a multidisciplinary approach, although with marked variability in team composition, expertise, and resources. Core specialists were available in most centres, while paediatric expertise was often lacking. Advanced neurophysiological monitoring and antiseizure medication level assessment were not uniformly accessible. Magnetic Resonance imaging was widely available, whereas Positron Emission Tomography was less consistently implemented. No centre had a dedicated clinical pathway for brain tumour-related epilepsy, despite the presence of pathways for brain tumours and epilepsy separately. Neuropsychological and comorbidity assessments were inconsistently integrated into care.

conclusionsThese findings highlight significant heterogeneity in the management of brain tumour-related epilepsy, even in highly specialized settings. The development of dedicated, standardized clinical pathways is needed to harmonize care and improve patient outcomes.

Indexed as

Brain NeoplasmsDelivery of Health Care, IntegratedEpilepsyHumansItalyMagnetic Resonance ImagingBrain tumourBrain tumour-related epilepsyClinical pathwaysEpilepsyMultidisciplinary careNeuro-oncology

Identifiers

PMID42350833
PMCPMC13303563

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.