Advances in electrochemical peptide synthesis and modification.

Dhanya Karipal Padinjare Veedu, Flynn C Attard, Esteban Suárez-Picado, Saurabh K Ahirwar, Lara R Malins

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In one paragraph

Review in Nature reviews. Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Dhanya Karipal Padinjare Veedu *Research School of Chemistry, The Australian National University, Canberra, Australian Capital Territory, Australia.

Flynn C Attard *Research School of Chemistry, The Australian National University, Canberra, Australian Capital Territory, Australia.ORCID 0009-0003-7574-9059

Esteban Suárez-PicadoResearch School of Chemistry, The Australian National University, Canberra, Australian Capital Territory, Australia.ORCID 0000-0003-1161-8175

Saurabh K AhirwarResearch School of Chemistry, The Australian National University, Canberra, Australian Capital Territory, Australia.

Lara R MalinsResearch School of Chemistry, The Australian National University, Canberra, Australian Capital Territory, Australia. lara.malins@anu.edu.au.ORCID 0000-0002-7691-6432

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To meet demand for bioactive, homogeneously modified peptides for both fundamental research and therapeutic development, synthetic methods that are programmable, broadly applicable and inherently sustainable are urgently needed. The mild reaction conditions and precise tunability of electrochemical transformations provide appealing opportunities to carefully navigate the rich redox-active landscape of canonical and non-canonical amino acid functionalities. Modern technological breakthroughs in synthetic electro-organic chemistry are further expanding capabilities, propelling the field of electrochemical peptide modifications into an era of accelerating innovation. This Review highlights recent advances (2020-present) in electrochemical peptide synthesis and residue-specific modifications in a graphically rich format that emphasizes the expanding diversity of available electrochemical strategies and their broader compatibility with complex peptide substrates. Outstanding challenges and opportunities for further innovation are discussed.

Indexed as

PeptidesAmino AcidsElectrochemical TechniquesOxidation-ReductionAmino AcidsPeptides

Identifiers

PMID42350807

DOI10.1038/s41467-023-40534-0

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.