Evidence map›Paper›PMID 42350792›Full record

ArticleNature2026

Base editing reveals an essential role for NANOG in human embryogenesis.

Oliver J Bower, Ana E R Orsi, Riley McMahon, Desislava Staneva, Josephine R Blagrove, Kashish Singh, Claire S Simon, Afshan McCarthy, Patricia Garcia, Valerie Shaikly and 15 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Oliver J BowerLoke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Ana E R OrsiLoke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0002-4939-1423
Riley McMahonLoke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Desislava StanevaLoke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-1330-2158
Josephine R BlagroveLoke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0003-2765-3514
Kashish SinghMRC Laboratory of Molecular Biology, Cambridge, UK.ORCID http://orcid.org/0000-0002-9891-8148
Claire S SimonLoke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.ORCID http://orcid.org/0000-0001-9614-1403
Afshan McCarthyHuman Embryo and Stem Cell Laboratory, The Francis Crick Institute, London, UK.
Patricia GarciaAssisted Reproduction and Gynaecology Centre, London, UK.ORCID http://orcid.org/0009-0009-9499-9401
Valerie ShaiklyAssisted Reproduction and Gynaecology Centre, London, UK.
Mohamed TaranissiAssisted Reproduction and Gynaecology Centre, London, UK.
Martin WildingCreate Fertility, London, UK.ORCID http://orcid.org/0000-0003-1829-6850
Paul SerhalCentre for Reproductive and Genetic Health, London, UK.
Rabi A OdiaCentre for Reproductive and Genetic Health, London, UK.
Mina VasilicCentre for Reproductive and Genetic Health, London, UK.
Meenakshi ChoudharyNewcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK.
Athanasios PapathanasiouBourn Hall Clinic, Bourn, UK.
Kay ElderBourn Hall Clinic, Bourn, UK.ORCID http://orcid.org/0000-0003-3510-8268
Phil SnellBourn Hall Clinic, Bourn, UK.
Leila ChristieBourn Hall Clinic, Bourn, UK.
Mandana ArbabRosamund Stone Zander Translational Neuroscience Center, Boston Children's Hospital, Boston, MA, USA.
David R LiuMerkin Institute of Transformative Technologies in Healthcare, Broad Institute of Harvard and MIT, Cambridge, MA, USA.
Mary HerbertNewcastle Fertility Centre, Newcastle upon Tyne Hospitals NHS Trust, Biosciences Institute, Newcastle University Centre for Life, Newcastle upon Tyne, UK.
Katarina HarasimovLoke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. kh767@cam.ac.uk.ORCID http://orcid.org/0000-0003-2703-4342
Kathy K NiakanLoke Centre for Trophoblast Research, Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK. kkn21@cam.ac.uk.ORCID http://orcid.org/0000-0003-1646-4734

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding how the first cell lineages in human development are specified and maintained has fundamental importance and clinical implications for regenerative medicine, infertility and pregnancy loss. Although mouse models have provided valuable insights into transcription factors regulating early development, translating these findings to human embryos has been limited by ethical, technical and biological constraints. Functional studies of transcription factors in human embryos have been hindered by nuclease-based genome editing approaches that induce genotoxicity

Identifiers

PMID42350792

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.