Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2026
Feasibility of tooth brushing during prolonged neutropenia in adults receiving intensive induction for acute leukemia: a randomized trial.
Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDue to potential bleeding and/or infectious complications, tooth brushing is contraindicated in some centers in patients with acute leukemia with prolonged neutropenia due to intensive induction therapy while there is limited data to support or not this strategy. The goal of this study is to confirm the safety of tooth brushing in these patients to improve patient comfort.
methodsWe randomized patients with acute leukemia undergoing intensive induction therapy to a mouthwash only strategy (control group) or a tooth brushing strategy (experimental arm) in a single center to verify the safety of tooth brushing in these patients. The oral assessment guide (OAG) was used as the primary endpoint to assess oral health during induction therapy. Other endpoints used to assess the safety tooth brushing included global and buccal bleeding complications, infectious complications, daily tolerance of oral hygiene protocols, and proportion of patients that discontinued the allocated oral hygiene procedure.
resultsBetween July 2019 and February 2023, we randomized 76 patients between the two strategies. The mean OAG scores were not different between the two groups (mean [standard deviation], 13.7 [2.9] vs. 13.1 [4.3] in the tooth brushing group, P = 0.47). While pain during the allocated hygiene protocol was similar in the two groups, tolerance was lower in the control group (6 [5-8] vs. 5 [3-6] in the tooth brushing group, P = 0.03). On the other hand, patients in the control group were less likely to discontinue the allocated oral hygiene protocol (6 vs. 32% in the tooth brushing group, P = 0.01). Other parameters, including oral mucositis, bleeding, and infections were not different between the two groups.
conclusionsWhile there was a higher discontinuation rate in the experimental group, this was partially due to local buccal mucosae injury with similar rates of adverse events between the two groups. This study suggests the safety of tooth brushing in patients with acute leukemia undergoing intensive induction therapy.
Indexed as
Identifiers
42350710What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.