ReviewCalcified tissue international2026
The Important Role of Polycystin in the Skeletal System.
Review in Calcified tissue international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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0 citing papers in PubMed.
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Authors and funding
6 authors.
Funding
Abstract
The polycystin (PC) protein family, including Polycystin-1 (PC1) and Polycystin-2 (PC2), was initially identified for its role in autosomal dominant polycystic kidney disease (ADPKD). Recent studies reveal that these mechanosensitive proteins play significant roles in skeletal development, homeostasis, and disease. PC1 and PC2 participate in mechanotransduction in bone cells and regulate the differentiation and function of osteoblasts, osteoclasts, and other skeletal cells through multiple signaling pathways, thereby influencing bone remodeling. Dysregulation of PC signaling is associated with various skeletal disorders, including osteoporosis, impaired fracture healing, craniosynostosis, and maxillofacial abnormalities. This review summarizes the structure, expression, molecular mechanisms, and clinical significance of polycystins in the skeletal system. We discuss their roles in different bone cell types, the signaling pathways involved, and emerging therapeutic strategies targeting PC-mediated mechanotransduction. Understanding the mechanosensitive functions of polycystins in bone provides a theoretical basis for developing new approaches to prevent and treat skeletal diseases. Further research on mechanisms and therapeutic applications will help elucidate bone metabolism regulation and advance clinical management of related conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.