Evidence map›Paper›PMID 42350637›Full record

ArticleJournal of neurology2026

Long-term outcomes after non-aneurysmal, non-traumatic subarachnoid hemorrhage: a prospective multicenter outcome study.

Wouter J Dronkers, Femke Geelen, Alyson Gross, René van den Berg, Jonathan M Coutinho, Luca Regli, W Peter Vandertop, Dagmar Verbaan, Menno R Germans

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Wouter J DronkersDepartment of Neurosurgery, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, room, H2-259, 1105 AZ, Amsterdam, The Netherlands. w.j.dronkers@amsterdamumc.nl.ORCID http://orcid.org/0000-0001-7684-1787
Femke Geelen *Department of Neurosurgery, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, room, H2-259, 1105 AZ, Amsterdam, The Netherlands.
Alyson Gross *Department of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
René van den BergNeurovascular Disease, Amsterdam Neurosciences, Meibergdreef 9, Amsterdam, The Netherlands.
Jonathan M CoutinhoNeurovascular Disease, Amsterdam Neurosciences, Meibergdreef 9, Amsterdam, The Netherlands.
Luca RegliDepartment of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.
W Peter VandertopDepartment of Neurosurgery, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, room, H2-259, 1105 AZ, Amsterdam, The Netherlands.
Dagmar VerbaanDepartment of Neurosurgery, Amsterdam UMC location University of Amsterdam, Meibergdreef 9, room, H2-259, 1105 AZ, Amsterdam, The Netherlands.
Menno R GermansDepartment of Neurosurgery, University Hospital Zurich, University of Zurich, Zurich, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNon-aneurysmal, non-traumatic subarachnoid hemorrhage (nSAH) refers to cases where a causative aneurysm cannot be identified. Stratification into perimesencephalic non-aneurysmal SAH (PMSAH) and non-perimesencephalic non-aneurysmal subarachnoid hemorrhage (NPSAH) is important for clinical purposes. The nSAH patients, in particular PMSAH patients, tend to have a better prognosis, as compared with aneurysmal subarachnoid hemorrhage patients. We prospectively studied functional outcome, return to work (RTW) status, quality of life and residual symptoms at least one year after the hemorrhage in these patients.

methodsThis multicenter study, conducted in Amsterdam UMC (Netherlands) and University Hospital Zurich (Switzerland), included adult nSAH patients admitted between 2015 and 2021. Outcomes, including the modified Rankin Scale (mRS), RTW status, the EuroQol-5Dimensions, EuroQol-Visual Analogue Scale, the Checklist Cognition and Emotion 24 items, and the Stroke-Specific Quality of Life Scale were prospectively assessed.

resultsOf 262 potential participants, 111 patients (66 NPSAH and 45 PMSAH; response rate 42%) returned the questionnaire, whereas 109 (41%) patients completed the telephone interview. The median follow-up time was 58.2 months (range 28.9-72.3). An mRS-score of ≥2 was recorded in 44 (40%) patients. Among 85 of 87 (RTW status missing in two patients) previously employed patients at the time of the hemorrhage, 61 (70%) fully RTW, 11 (13%) partially RTW, and 13 (15%) did not return to work. Twenty-eight (26%) patients had no complaints at all at follow-up. Frequently reported residual symptoms involved increased tiredness and difficulties remembering new information.

conclusionsLong-term follow-up of nSAH patients reveals that 40% reports an mRS-score of ≥2. Furthermore, 28% of previously employed patients did not (fully) return to work and the majority of patients reports residual symptoms at follow-up. Our findings show that a larger part of non-aneurysmal, non-traumatic SAH patients can not resume all previous activities than previously reported, even at long-term follow-up.

Indexed as

Outcome Assessment, Health CareReturn to WorkSubarachnoid HemorrhageAdultAgedFemaleFollow-Up StudiesHumansMaleMiddle AgedProspective StudiesQuality of LifeOutcomeReturn to workSubarachnoid hemorrhage

Identifiers

PMID42350637
PMCPMC13303305

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.