Collagen promotes PD-L1 overexpression in fibroblasts through binding to CD44 and activating YAP1 signaling during keloid formation.

Lingfeng Chen, Yakun Gao, Sida Pan, Zhu Zhu, Jianlan Liu, Ningwen Zhu, Baojin Wu

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Lingfeng ChenDepartment of Plastic Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Yakun GaoDepartment of Plastic Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Sida PanDepartment of Plastic Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Zhu ZhuDepartment of Plastic Surgery, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Jianlan LiuDepartment of Dermatology, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Ningwen ZhuDepartment of Plastic Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China.

Baojin WuDepartment of Plastic Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China. wubaojin@fudan.edu.cn.

Funding

National Natural Science Foundation of China 82002042

6 · The paper itself

Abstract

Keloid is a skin collagen disease secondary to skin injury, characterized by excessive collagen deposition and a markedly high rate of recurrence. To date, there is still a lack of effective prevention and treatment methods for keloid. Thus, it is urgent to explore the main pathological mechanism of keloid formation, which requires to identify the biological mechanism of deposited collagen regulating the formation of fibroblast-mediated local immunosuppressive microenvironment. Collagen accumulation, CD4

Indexed as

Adaptor Proteins, Signal TransducingB7-H1 AntigenCollagenCollagen Type IFibroblastsHyaluronan ReceptorsKeloidTranscription FactorsAdultCells, CulturedFemaleHumansMaleSignal TransductionYAP-Signaling ProteinsAdaptor Proteins, Signal TransducingB7-H1 AntigenCD274 protein, humanCD44 protein, humanCollagenCollagen Type IHyaluronan ReceptorsTranscription FactorsYAP1 protein, humanYAP-Signaling ProteinsCD44CollagenFibroblastKeloidPD-L1YAP1 signaling

Identifiers

PMID42350631

DOI10.1038/s41598-026-59337-6

PMCPMC13438748

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.