Evidence map›Paper›PMID 42350620›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Sedative use in infants with grade 3 bronchopulmonary dysplasia (BPD) and associations with neurodevelopmental therapies.

Thomas J Davis, Gangaram Akangire, Brianna K Brei, Matthew Coyle, Bridget DiPrisco, Tara DuPont, Susan Gage, Melissa Hanin, Melissa House, Khanh Lai and 6 more

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Thomas J DavisDepartment of General Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0003-2744-6937
Gangaram AkangireDivision of Neonatology, Children's Mercy Hospital, Kansas City, MO, USA.ORCID http://orcid.org/0000-0001-7796-7672
Brianna K BreiDivision of Neonatology, Children's Nebraska, Omaha, NE, USA.
Matthew CoyleDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
Bridget DiPriscoDivision of Neonatology, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Tara DuPontDepartment of Neonatology, Health Science Center, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-1159-5279
Susan GageDepartment of Neonatology, Children's Hospital of Orange County, Orange, CA, USA.
Melissa HaninDepartment of Neonatology, Nationwide Children's Hospital, Columbus, OH, USA.
Melissa HouseDepartment of Neonatology, Emory School of Medicine, Atlanta, GA, USA.ORCID http://orcid.org/0000-0003-1426-5889
Khanh LaiDepartment of Neonatology, Health Science Center, Salt Lake City, UT, USA.
Audrey N MillerDepartment of Neonatology, Nationwide Children's Hospital, Columbus, OH, USA.ORCID http://orcid.org/0000-0001-6222-3515
Divya RanaDepartment of Neonatology, The University of Tennessee Health Science Center, Memphis, TN, USA.ORCID http://orcid.org/0000-0002-3720-9495
Karishma RaoDivision of Neonatology, Children's Mercy Hospital, Kansas City, MO, USA.
Meaghan A RansomDivision of Neonatology, Vanderbilt University Medical Center, Nashville, TN, USA.
Laura SillersDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.ORCID http://orcid.org/0000-0002-0484-4150
Sara B DeMauroDivision of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA. DEMAURO@chop.edu.ORCID http://orcid.org/0000-0003-1647-4000

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesTo characterize sedative and analgesic use in NICU patients with grade 3 bronchopulmonary dysplasia (BPD) in relation to respiratory support and neurodevelopmental therapies. SUBJECTS/

methodsPoint-prevalence survey across 22 NICUs of infants <24 months corrected age with grade 3 BPD who had never been discharged. Exclusions included recent sepsis, tracheostomy, or major surgery. Data were analyzed descriptively.

resultsAmong 141 infants, 97 (69%) received ≥1 sedative within 48 hours; 73 (75%) received multiple (mean 2.8 ± 1.6). Alpha-agonizts (n=67) and benzodiazepines (n=65) were most common, with 27 infants receiving an alpha-agonist, opioid, and benzodiazepine combination. Sedative exposure and medication count correlated with higher respiratory support (p<0.001) and FiO₂ (r=0.28, p<0.01). Sedation was associated with fewer completed therapy sessions (z=3.3, p<0.001).

conclusionSedation and polypharmacy were frequent among infants with severe BPD and linked to reduced therapy participation, highlighting the need to assess prescribing rationale and neurodevelopmental impacts.

Identifiers

PMID42350620

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