Evidence map›Paper›PMID 42350407›Full record

ArticleNature communications2026

Three immunoregulatory signatures define non-productive HIV infection in stem cell memory CD4

Giacomo M Butta, Bremy Alburquerque, Charlotte Kearns, Yoav Hadas, Max W VanDyck, Susanna Scaglioni, Noah Peña, Hoi Tong Wong, Elizabeth Levendosky, Charles Gleason and 5 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Giacomo M ButtaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-9429-4270
Bremy AlburquerqueDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-9115-8318
Charlotte KearnsDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0009-0004-3304-9684
Yoav HadasDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Max W VanDyckDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Susanna ScaglioniDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-5118-7061
Noah PeñaDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-9079-4638
Hoi Tong WongDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Elizabeth LevendoskyDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0001-6230-1851
Charles GleasonDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Xiao LinDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0002-2559-2343
Lara ManganaroDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID http://orcid.org/0000-0003-2743-2658
Dalila PintoDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, USA. dalila.pinto@mssm.edu.ORCID http://orcid.org/0000-0002-8769-0846
Lubbertus C F MulderDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. lubbertus.mulder@mssm.edu.ORCID http://orcid.org/0009-0004-1731-2796
Viviana SimonDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. viviana.simon@mssm.edu.ORCID http://orcid.org/0000-0002-6416-5096

Funding

THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4M
Determinants of HIV latency in CD4+ T lymphocytesR01AI179598 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Viviana A Simon · 2024 to 2026
$2.5M
NCI NIH HHS P30 CA196521NIAID NIH HHS R01 AI179598U.S. Department of Health & Human Services | NIH | National Institute of Allergy and Infectious Diseases (NIAID) AI179598
6 · The paper itself

Abstract

The persistent HIV reservoir constitutes the main obstacle to curing HIV/AIDS disease. Our understanding of how non-productive HIV infections are established in primary human CD4

Indexed as

CD4-Positive T-LymphocytesHIV-1HIV InfectionsImmunologic MemoryMemory T CellsStem CellsGene Expression ProfilingHumansIndoleamine-Pyrrole 2,3,-DioxygenaseProvirusesReceptors, CCR4TranscriptomeIndoleamine-Pyrrole 2,3,-DioxygenaseReceptors, CCR4

Identifiers

PMID42350407
PMCPMC13447973

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.