Evidence map›Paper›PMID 42349790›Full record

ReviewThe Journal of biological chemistry2026

Orchestrating glucose metabolism: PFKFB2 as a signal-integrating conductor in homeostasis and disease.

Kylene M Harold, Wan Hee Yoon, Kenneth M Humphries

Abstract readReview
In one paragraph

Review in The Journal of biological chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kylene M HaroldDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma, USA; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma, USA.
Wan Hee YoonAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma, USA.
Kenneth M HumphriesDepartment of Biochemistry and Physiology, University of Oklahoma Health Sciences Center, Oklahoma, USA; Aging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma, USA. Electronic address: kenneth-humphries@omrf.org.

Funding

Viral sensor IFIH1 promotes SLE through an altered interferon programP20GM139763 · NIGMS · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI Lijun Xia · 2021 to 2026
$20.3M
Increasing glycolysis in the diabetic heart is cardioprotective and improves glucose toleranceR01HL160955 · NHLBI · OKLAHOMA MEDICAL RESEARCH FOUNDATION · PI HUMPHRIES, KENNETH M · 2022 to 2025
$1.7M
Impacts of Phosphofructokinase-2 on Cardiac Electrophysiology and Function in DiabetesF31HL176095 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HAROLD, KYLENE MARIE · 2025 to 2025
$38k
NHLBI NIH HHS F31 HL176095NHLBI NIH HHS R01 HL160955NIGMS NIH HHS P20 GM139763
6 · The paper itself

Abstract

As a bifunctional enzyme, phosphofructokinase-2/fructose 2,6-bisphosphatase (PFKFB or PFK-2) produces and degrades fructose-2,6-bisphosphate (Fru-2,6-P

Indexed as

GlucoseHomeostasisPhosphofructokinase-2AnimalsHumansSignal TransductionGlucosePFKFB2 protein, humanPhosphofructokinase-2ancillary pathwaysfructose 2,6-bisphosphateglucose metabolismglycolysisglycolytic regulationmetabolic regulationphosphofructokinase

Identifiers

PMID42349790
PMCPMC13446353

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.