Trial reportThe Journal of nutrition2026
Higher Maternal Body Mass Index Attenuates the Response to High-Dose Vitamin D Supplementation During Pregnancy: A Secondary Analysis of the Randomized Vitamin D Antenatal Asthma Reduction Trial (VDAART).
Trial report in The Journal of nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00920621 (Randomized Trial), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Randomized Trial: Maternal Vitamin D Supplementation to Prevent Childhood Asthma (VDAART)
Who cites it
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Authors and funding
7 authors.
Funding
Abstract
backgroundVitamin D supplementation during pregnancy is recommended to optimize maternal vitamin D status, yet biochemical response is highly variable, potentially limiting attainment of adequate 25-hydroxyvitamin D [25(OH)D] concentrations. Maternal body mass index (BMI) may modify vitamin D response, but this relationship has not been comprehensively examined in randomized trials conducted during pregnancy.
objectivesThis study examines whether maternal BMI modifies the biochemical response to high-dose vitamin D supplementation during pregnancy.
methodsUsing data from the vitamin D antenatal asthma reduction trial, a randomized, double-blind trial of pregnant participants, we examined whether maternal BMI modifies response to high-dose (110 μg/d) compared with standard-dose (10 μg/d) vitamin D supplementation. Maternal serum 25(OH)D was measured at enrollment (10‒18 wk) and in the third trimester (32‒38 wk). Linear mixed-effects models examined the interaction between treatment group and BMI (categories <25, 25‒29.9, and ≥30; continuous; and ordinal), adjusting for baseline 25(OH)D and demographic and clinical covariates.
resultsAmong 816 participants in the intention-to-treat analysis, high-dose supplementation increased maternal 25(OH)D by 22.43 nmol/L [95% confidence interval (CI): 17.16, 27.70 nmol/L; P < 0.001] versus standard-dose supplementation among those with BMI <25 kg/m
conclusionsMaternal BMI attenuates the biochemical response to vitamin D supplementation during pregnancy in a graded, BMI-dependent manner. Although most participants receiving 110 μg/d achieved 25(OH)D concentrations ≥50 nmol/L, higher BMI was associated with a smaller increase in 25(OH)D and a greater likelihood of remaining below the higher 75 nmol/L target. These findings suggest that uniform prenatal supplementation strategies may not fully account for BMI-related differences in vitamin D response. Future studies should determine whether BMI-stratified dosing improves achieved vitamin D status and translates into better maternal or offspring outcomes. This trial was registered at clinicaltrials.gov as NCT00920621.
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