Evidence map›Paper›PMID 42349735›Full record

ArticleActa biomaterialia2026

Long-term remodeling of compliance matched tissue engineered vascular grafts is sex specific.

Katarina M Martinet, David R Maestas, Leon X Min, Reyhaneh Gholami, Keishi Kohyama, Jacqueline L Avila, Sang Ho Ye, Kang Kim, William R Wagner, Jonathan P Vande Geest

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta biomaterialia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Katarina M MartinetDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
David R MaestasDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Leon X MinDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Reyhaneh GholamiDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Keishi KohyamaDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Jacqueline L AvilaDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Sang Ho YeDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA.
Kang KimDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Department of Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
William R WagnerDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA; Department of Surgery, University of Pittsburgh, Pittsburgh, PA, USA; Department of Chemical and Petroleum Engineering, University of Pittsburgh, Pittsburgh, PA, USA.
Jonathan P Vande GeestDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, PA, USA; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA, USA. Electronic address: jpv20@pitt.edu.

Funding

Cardiovascular Bioengineering Training ProgramT32HL076124 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SANJEEV G SHROFF · 2005 to 2026
$7.0M
Preclinical Assessment of a Compliance Matched Biopolymer Vascular Graft - Diversity SupplementR01HL157017 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI VANDE GEEST, JONATHAN PIETER · 2022 to 2025
$3.1M
Advanced High Resolution Rodent Ultrasound Imaging SystemS10OD023684 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KIM, KANG · 2018 to 2018
$390k
Sex Specific Differences in the Remodeling of a Biopolymer Based Tissue Engineered Vascular GraftF31HL176056 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Katarina Martinet · 2025 to 2026
$100k
NHLBI NIH HHS F31 HL176056NHLBI NIH HHS R01 HL157017NHLBI NIH HHS T32 HL076124NIH HHS S10 OD023684
6 · The paper itself

Abstract

Compliance matching of tissue engineered vascular grafts (TEVGs) is a promising technique to combat common failure modes seen clinically in small diameter vascular procedures like coronary artery bypass grafting (CABG). However, despite the influence of sex on vascular response to injury, the role of biological sex on the success of TEVG innovations such as compliance matching, namely in long-term remodeling, has been understudied. In this study we fabricated compliance matched TEVGs (CM TEVGs) and hypocompliant TEVGs (Hypo TEVGs) by adjusting the thicknesses of a high polyester urethane urea (PEUU) containing layer (80:20 PEUU:Gelatin) and a low PEUU containing layer (20:80 PEUU:Gelatin). All grafts were implanted into the abdominal aorta of both male and female Sprague Dawley rats (n = 4) as interposition grafts for 6 months and monitored using in vivo ultrasound. Upon explant, key outcomes of long-term remodeling were assessed via immunohistochemistry, multiphoton imaging, and qRT-PCR. CM TEVGs were confirmed to be compliance matched to native aorta both in vitro and in vivo upon implant. After remodeling, CM TEVGs had increased degradation and decreased calcification compared to Hypo TEVGs. CM TEVGs had increased mature VSMC genes (Acta2, Myh11, Cnn1) in males and decreased macrophage presence (CD68) in females. Independent of graft type, females had increased intimal thickening, decreased luminal presence of mature VSMCs, and increased fibrillar collagen deposition compared to males in both CM and Hypo TEVGs. Our results suggest that long-term remodeling outcomes in response to compliance matching are dependent on biological sex at both the tissue and cellular level.

Indexed as

Aorta, AbdominalBlood Vessel ProsthesisSex CharacteristicsTissue EngineeringAnimalsCD68 MoleculeFemaleMalePolyestersPolyurethanesRatsRats, Sprague-DawleyCD68 MoleculePolyesterspoly(ester urethane)ureaPolyurethanesComplianceRatSex specific remodelingSmall animal ultrasoundTissue-engineered vascular graftVascular smooth muscle cell

Identifiers

PMID42349735
PMCPMC13404222

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.