Evidence map›Paper›PMID 42349424›Full record

ArticleStem cell reports2026

Elevated mitochondrial Ca

Ahmed S Shams, Lalitha S Denduluri, Megan K Sumera, Ingrid R Aragon, Lauren LaScala, Jae Hwi Sung, Sydney Peng, Sarah J Cornelius, Sana Ikramuddin, Aiden M Boechler and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ahmed S ShamsLillehei Heart Institute and Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA; Department of Human Anatomy and Embryology, Faculty of Medicine, Suez Canal University, Ismailia 41522, Egypt.
Lalitha S DenduluriDepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Megan K SumeraDepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Ingrid R AragonDepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Lauren LaScalaDepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Jae Hwi SungDepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Sydney PengLillehei Heart Institute and Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Sarah J CorneliusLillehei Heart Institute and Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Sana IkramuddinLillehei Heart Institute and Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Aiden M BoechlerLillehei Heart Institute and Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Eric BatchelorDepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Michael KybaLillehei Heart Institute and Department of Pediatrics, Medical School, University of Minnesota, Minneapolis, MN 55455, USA.
Julia C LiuDepartment of Integrative Biology and Physiology, Medical School, University of Minnesota, Minneapolis, MN 55455, USA. Electronic address: julialiu@umn.edu.

Funding

Probing the Activity of DUX4 in FSHDR01AR055685 · NIAMS · UNIVERSITY OF MINNESOTA · PI Michael Kyba · 2010 to 2026
$7.0M
Dissecting Effects of Estrogen Deficiency on Satellite Cells and Muscle Regeneration in Females and MalesR01AG062899 · NIA · UNIVERSITY OF MINNESOTA · PI KYBA, MICHAEL, LOWE, DAWN A · 2019 to 2023
$2.5M
Modulating mitochondrial calcium in cardiac homeostasis and diseaseR01HL164491 · NHLBI · UNIVERSITY OF MINNESOTA · PI Julia Chang Liu · 2022 to 2026
$2.2M
The roles of p53 and MYC dynamics in regulating heterogeneous cell fate responses to genotoxic stressR01GM149666 · NIGMS · UNIVERSITY OF MINNESOTA · PI Eric Batchelor · 2023 to 2026
$1.3M
Molecular mechanism and physiological function of mitochondrial calcium regulationK22HL137901 · NHLBI · UNIVERSITY OF MINNESOTA · PI LIU, JULIA CHANG · 2020 to 2022
$747k
NHLBI NIH HHS K22 HL137901NHLBI NIH HHS R01 HL164491NIAMS NIH HHS R01 AR055685NIA NIH HHS R01 AG062899NIGMS NIH HHS R01 GM149666
6 · The paper itself

Abstract

MICU1 loss-of-function variants in human patients are associated with proximal muscle weakness and myopathy. Mitochondrial Ca

Indexed as

CalciumMitochondriaMuscle, SkeletalSatellite Cells, Skeletal MuscleAnimalsCalcium-Binding ProteinsCation Transport ProteinsCell ProliferationMiceMitochondrial Membrane Transport ProteinsMuscle DevelopmentPAX7 Transcription FactorRegenerationCalciumCalcium-Binding ProteinsCation Transport ProteinsMICU1 protein, mouseMitochondrial Membrane Transport ProteinsPAX7 Transcription FactoractivationcalciumMICU1mitochondriamyogenesisquiescencerespirationsatellite cellsself-renewaltransplantation

Identifiers

PMID42349424
PMCPMC13385437

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.