Evidence map›Paper›PMID 42349413›Full record

ArticleCell reports. Medicine2026

GPNMB

Jialin Jiang, Fanqi Kong, Bing Zheng, Zijian Mei, Jian Zhu, Ximing Xu, Weicheng Pan, Ziran Wang, Xiaofei Sun, Kaiqiang Sun and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jialin JiangDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China.
Fanqi KongDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China; Department of Orthopedic Surgery, Orthopedic Institute, The First Affiliated Hospital of SooChow University, Suzhou, China.
Bing ZhengDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China.
Zijian MeiDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jian ZhuDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China.
Ximing XuDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China.
Weicheng PanDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China.
Ziran WangDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xiaofei SunDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China.
Kaiqiang SunDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China.
Le HuanDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jiangang ShiDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China. Electronic address: changzhengspine@smmu.edu.cn.
Huji XuDepartment of Rheumatology and Immunology, National Key Laboratory for Immunity and Inflammation, Changzheng Hospital, Naval Medical University, Shanghai, China; Peking-Tsinghua Center for Life Sciences, Tsinghua University, Beijing, China. Electronic address: xuhuji@smmu.edu.cn.
Yongfei GuoDepartment of Orthopedic Surgery, Spine Center, Changzheng Hospital, Naval Medical University, Shanghai, China. Electronic address: guospine@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Phenotypic transitions of nucleus pulposus (NP) cells are increasingly recognized as key drivers of intervertebral disc degeneration (IVDD), yet the differentiation fate of NP cells and its regulation by the immune microenvironment remain unclear. Using single-cell transcriptomic profiling with in vivo and in vitro validation, we identify an osteoblast-like NP cell subpopulation that emerges during IVDD and exhibits enhanced osteogenic differentiation capacity. Genetic disruption of NP cell osteogenic potential attenuates disc degeneration, supporting a causal role for this program in disease progression. We further show that GPNMB

Indexed as

Cell DifferentiationIntervertebral Disc DegenerationMacrophagesMembrane GlycoproteinsNucleus PulposusOsteogenesisPlatelet-Derived Growth FactorAnimalsEye ProteinsHumansMiceSignal TransductionEye ProteinsGpnmb protein, mouseMembrane GlycoproteinsPlatelet-Derived Growth Factorcell-cell communicationintervertebral disc degenerationmacrophagesnucleus pulposusosteogenic differentiationsingle-cell RNA sequencing

Identifiers

PMID42349413
PMCPMC13400173

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.