Evidence map›Paper›PMID 42349150›Full record

ReviewRedox biology2026

Metabolism, autophagy, and cell death: The triangular axis in tumor survival and therapeutic resistance.

Wen-Dong Wan, Muhammad Tufail, Can-Hua Jiang, Ning Li

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Redox biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Wen-Dong WanDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China.
Muhammad TufailDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China.
Can-Hua JiangDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China; Institute of Oral Precancerous Lesions, Central South University, Changsha, China; Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China.
Ning LiDepartment of Oral and Maxillofacial Surgery, Center of Stomatology, Xiangya Hospital, Central South University, Changsha, China; Institute of Oral Precancerous Lesions, Central South University, Changsha, China; Research Center of Oral and Maxillofacial Tumor, Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Electronic address: liningoms@csu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tumor cells face constant environmental and therapeutic stresses, relying on interconnected survival mechanisms involving autophagy, metabolism, and cell death regulation. This review explores the triangular relationship between these processes and how their dynamic interplay supports tumor growth and drives resistance to various treatments. We discuss key molecular pathways regulating autophagy and metabolic reprogramming, and their impact on different cell death modalities. Finally, we address current challenges in translating this knowledge into clinical therapies, emphasizing the need for precise biomarkers and combination strategies to overcome resistance. Understanding this complex network offers promising avenues for developing more effective cancer treatments.

Indexed as

AutophagyDrug Resistance, NeoplasmNeoplasmsAnimalsCell DeathCell SurvivalHumansMetabolic ReprogrammingSignal TransductionAutophagyCell deathMetabolic reprogrammingTherapeutic approachesTumor survival and resistance

Identifiers

PMID42349150
PMCPMC13320456

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.