Observational studyHuman vaccines & immunotherapeutics2026
Monitoring the safety of the adjuvanted human papillomavirus vaccine HPV-16/18-AS04 in association with pregnancy and potential immune-related diseases in China: A retrospective observational cohort study.
Observational study in Human vaccines & immunotherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Human papillomavirus (HPV) infection causes cervical cancer. The objective of the study is to monitor AS04-adjuvanted HPV-16/18 vaccine (Cervarix, GSK) safety in a real-world setting in China, using electronic health records from the Yinzhou Regional Health Information Platform (YRHIP). This retrospective observational cohort study included all permanent residents (males and females) aged 9-45 y with ≥12 months continuous YRHIP registration between 1 January 2010 and 31 December 2020. The study analyzed demographic information, diagnoses coded using International Classification of Diseases 10th Revision for potential immune-mediated diseases (pIMD) and pregnancy-related outcomes, and HPV vaccination records. Of 1,002,399 participants in the YRHIP, 891,463 met the eligibility criteria. In the age group 9-45 y, uptake of AS04-adjuvanted HPV-16/18 vaccine was 11.95/1000 persons. The incidence density for other spondylopathies, sarcoidosis, and pulmonary sarcoidosis was significantly higher in females vaccinated with any dose of AS04-adjuvanted HPV-16/18 vaccine compared with females who did not receive HPV vaccination during the study period (
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