SynthesisPloS one2026
Efficacy of adjunctive antibiotics compared to non-antibiotic therapies following mechanical debridement for peri-implantitis: A systematic review and meta-analysis of randomized controlled trials.
Synthesis in PloS one, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Azithromycin in Dentistry: From Systemic Antibiotic to a Candidate for Local Therapeutic Delivery.Pharmaceutics · 2026Review
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6 authors.
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Abstract
objectiveTo evaluate the efficacy of antibiotic therapy as an adjunct to mechanical debridement in peri-implantitis.
methodPubMed, Embase, Web of Science, the Cochrane Library, and Scopus were searched (inception to 15 January, 2026). Additionally, clinical trials were searched on ClinicalTrials.gov. Meta-analyses were performed to evaluate bone level (BL), bleeding on probing (BOP), probing pocket depth (PPD), clinical attachment level (CAL), modified plaque index (mPLI), plaque score (PS).
resultsTwenty-two RCTs were included. Adjunctive antibiotics with mechanical debridement demonstrated significant advantages in improving PPD (WMD = -0.69; 95% CI: [-1.04, -0.33]; P = 0.0001; heterogeneity:I2 = 91%, P < 0.00001), CAL (WMD = -0.55; 95% CI: [-1.07, -0.04]; P = 0.04; heterogeneity:I2 = 95%, P < 0.00001), PS (WMD = -4.07; 95% CI: [-6.80, -1.33]; P = 0.004; heterogeneity:I2 = 0%, P = 0.94), and BOP (WMD = -12.45; 95% CI: [-24.13, -0.77]; P = 0.04; heterogeneity:I2 = 94%, P < 0.00001). In the subgroup analysis comparing mechanical debridement plus antibiotics versus mechanical debridement alone, statistically significant improvements were observed for CAL (WMD = -0.84; 95% CI: [-1.55, -0.13]; P = 0.02) and PS (WMD = -3.94; 95% CI: [-7.14, -0.74]; P = 0.02), confirming clinical necessity of antibiotics as an adjunct to debridement. In the comparison of local versus systemic antibiotic administration, comparable efficacy in reducing PPD was observed for both local (WMD = -0.68; 95% CI: [-1.14, -0.22]; P = 0.004) and systemic (WMD = -0.70; 95% CI: [-1.25, -0.15]; P = 0.01) routes, with no significant difference between subgroups (P = 0.95, I² = 0%). For PS, local antibiotics (WMD = -6.57; 95% CI: [-11.10, -2.04]; P = 0.004) demonstrated significantly greater improvement compared to systemic antibiotics (WMD = -2.63; 95% CI: [-6.07, 0.80]; P = 0.13).
conclusionAs an adjunct to mechanical debridement, antibiotics may provide modest benefits for peri-implantitis, demonstrating efficacy in improving probing pocket depth, clinical attachment level, plaque score, bleeding on probing, and other parameters related to soft tissue health and plaque control. PROSPERO: CRD420261328879. Available from https://www.crd.york.ac.uk/PROSPERO/view/CRD420261328879.
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