ArticleRespiration; international review of thoracic diseases2026
Residual Apnoea-Hypopnoea Index Measurement from Positive Airway Pressure Devices versus Home Polygraphy: A Method Comparison Study Using Real-World Data.
Article in Respiration; international review of thoracic diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionResidual apnoea-hypopnoea index (AHI) derived from positive airway pressure (PAP) device downloads is frequently used to assess treatment effectiveness in obstructive sleep apnoea (OSA). However, the accuracy of device reported AHI in real-world settings remains uncertain. This study evaluated the agreement between PAP device-derived AHI and AHI measured using home-based cardiorespiratory polygraphy.
methodsThis secondary analysis of the 3DPiPPIn randomised controlled trial included adults with OSA (AHI ≥15 events/h) naïve to domiciliary PAP therapy. Participants underwent two-night home cardiorespiratory polygraphy at 3 and 6 months. Residual AHI was obtained from Löwenstein PAP devices via data download. Agreement between methods was assessed using Bland-Altman analysis, intraclass correlation coefficients (ICCs), and weighted Kappa. Sensitivity and specificity for detecting inadequate control (AHI ≥7 events/h) were calculated. The association between average leak and AHI discrepancy was examined using linear regression.
resultsNinety-eight participants were included. PAP-derived AHI values consistently underestimated polygraphy-derived AHI across all time points. Agreement was poor, with ICCs of 0.02 at 3 months and 0.16 at 6 months and low diagnostic agreement across severity categories at both 3 months (
conclusionPAP device downloads substantially underestimated residual AHI and demonstrated poor agreement with home cardiorespiratory polygraphy. These findings highlight important limitations of device-derived AHI in real-world practice, particularly in the presence of interface leak. Where treatment adequacy is uncertain, confirmatory assessment with polygraphy remains necessary.
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