ArticleJournal of vascular research2026
Exploring Sexual Dimorphism and Genetic Variability in Cutaneous Microhemodynamics in BALB/c, C57BL/6J, and KM Mice.
Article in Journal of vascular research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
introductionThe comprehensive functionality of the cutaneous microcirculation extends beyond its barrier properties, implicating it in thermoregulation, nutrient exchange, and systemic disease pathophysiology. Our study aimed to investigate the sex- and strain-specific differences in cutaneous microvascular function and their relationships with systemic hemodynamics, skin physiology, and sex hormone-related metabolites in BALB/c, C57BL/6J, and KM mice.
methodsWe analyzed sex- and strain-specific cutaneous microhemodynamics to elucidate the impact of genetic and hormonal factors on microvascular function. Our multidimensional approach incorporated body mass, glycemic levels, cardiovascular profiles, along with histological and immunohistochemical analyses, flagging discernible sexual dimorphism and inter-strain variability.
resultsImmunohistochemical staining revealed significantly higher estrogen receptor expression within the male cutaneous microcirculation for BALB/c and C57BL/6J strains. Laser Doppler flowmetry and wavelet transform analysis revealed significant sex-specific and inter-strain differences in cutaneous microvascular blood perfusion, RBC concentration, and blood flow velocity. Sexual dimorphism was evident in the KM strain across all examined amplitudes, with males typically displaying greater variability. Similar wavelet statistical analysis results in microhemodynamic indicators suggest the homeostasis of specific frequency contributions. Furthermore, we observed significant correlations between systemic hemodynamics and cutaneous microcirculatory function, with heart rate and blood pressure variably associated with microvascular flow, erythrocyte concentration, and blood perfusion dynamics across strains and sexes.
conclusionThese findings indicate the complexities of cutaneous microhemodynamics, emphasizing the interplay between genetic lineage and sex-based differences.
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