Evidence map›Paper›PMID 42348434›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

The KIF6-RBP Complex Orchestrates mRNA Transport Required for Sperm Flagellar Assembly.

Chunbo Xie, Sibing Yi, Xinle Lin, Shen Zhang, Weili Wang, Shimin Yuan, Lanlan Meng, Yong Li, Chen Tan, Chunjia Wei and 11 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Chunbo XieInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Sibing YiInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Xinle LinInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Shen ZhangInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Weili WangInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Shimin YuanInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Lanlan MengInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Yong LiInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Chen TanInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Chunjia WeiInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Yanyan YuInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Yaoqiong LiangInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Huan ZhangInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Liang HuInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Guangxiu LuInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Wenbin HeClinical Research Center for Reproduction and Genetics in Hunan Province, Reproductive & Genetic Hospital of CITIC-Xiangya, Changsha, China.ORCID https://orcid.org/0000-0002-1966-5075
Qianjun ZhangInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Juan DuInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.ORCID https://orcid.org/0000-0002-5701-6703
Ge LinInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.
Chaofeng TuInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.ORCID https://orcid.org/0000-0001-5682-8948
Yue-Qiu TanInstitute of Reproduction and Stem Cell Engineering, Xiangya School of Basic Medical Sciences, Central South University, Changsha, China.ORCID https://orcid.org/0000-0002-8359-4654

Funding

Major Scientific Program of CITIC Group 2023ZXKYB34100National Key Research and Development Program of China 2023YFC2705605National Natural Science Foundation of China 22574175National Natural Science Foundation of China 82201773National Natural Science Foundation of China 82371628National Natural Science Foundation of China 82401885National Natural Science Foundation of China 82471652National Natural Science Foundation of China U23A20402Natural Science Foundation of Hunan Province 2023JJ30731Natural Science Foundation of Hunan Province 2025JJ50602Postgraduate Research and Innovation Project of Hunan Province CX20250341Research Grant of CITIC-XIANGYA YNXM-202211Research Grant of CITIC-XIANGYA YNXM-202313Science and Technology Innovation Program of Hunan Province 2024RC3027
6 · The paper itself

Abstract

The precise assembly of the sperm flagellum is essential for male fertility and has long been ascribed to kinesin-2-driven intraflagellar transport (IFT) of protein cargoes. However, during late spermiogenesis, when transcription activity is largely silenced, how the spatiotemporally regulated delivery of flagellar components remains poorly understood. Here, we systematically screened kinesin genes in asthenozoospermic patients and identified two homozygous deleterious KIF6 variants in unrelated men characterized by complete sperm immotility. Mouse models carrying the corresponding mutations recapitulated the human infertility phenotypes. Multi-omics analyses revealed that most testicular mRNAs remained largely unchanged in Kif6

Indexed as

AsthenozoospermiaKinesinsRNA-Binding ProteinsRNA, MessengerRNA TransportSperm TailAnimalsFlagellaHumansMaleMiceSpermatogenesisKinesinsRNA-Binding ProteinsRNA, Messengerasthenozoospermiaflagellar assemblyKIF6mRNA transportRNA‐binding protein

Identifiers

PMID42348434
PMCPMC13335463

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.