Evidence map›Paper›PMID 42348420›Full record

ArticleCell reports2026

The calcium pump ATP2B1/PMCA1 regulates CNS vascular development by facilitating Norrin- and WNT7A/B-induced Frizzled4 signaling.

Ha-Neul Jo, Elizabeth Kiffmeyer, Chi Zhang, Lingling Zhang, Emmanuel Odame, Quynh Chau Dinh, Jacklyn Levey, Miranda Howe, Kyle J Roux, Klaus-Dieter Fischer and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Ha-Neul JoUniversity of Minnesota, Graduate Program in Molecular, Cellular, Developmental Biology, and Genetics, Minneapolis, MN, USA; University of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA.
Elizabeth KiffmeyerUniversity of Minnesota, Department of Neuroscience, Minneapolis, MN, USA.
Chi ZhangDepartment of Ophthalmology, Vagelos College of Physicians and Surgeons, Columbia University Irving Medical Center, New York, NY, USA; Mortimer B. Zuckerman Mind Brain Behavior Institute, Columbia University, New York, NY, USA.
Lingling ZhangUniversity of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA; University of St. Thomas, Department of Biology, Saint Paul, MN, USA.
Emmanuel OdameUniversity of Minnesota, Graduate Program in Molecular, Cellular, Developmental Biology, and Genetics, Minneapolis, MN, USA; University of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA.
Quynh Chau DinhUniversity of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA.
Jacklyn LeveyUniversity of Minnesota, Graduate Program in Molecular, Cellular, Developmental Biology, and Genetics, Minneapolis, MN, USA; University of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA.
Miranda HoweUniversity of Minnesota, Graduate Program in Molecular, Cellular, Developmental Biology, and Genetics, Minneapolis, MN, USA; University of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA.
Kyle J RouxEnabling Technology Group, Sanford Research, Sioux Falls, SD, USA; Department of Pediatrics, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA.
Klaus-Dieter FischerInstitute for Biochemistry and Cell Biology, Otto-von-Guericke University, Medical Faculty, Magdeburg, Germany.
Zhe ChenUniversity of Minnesota, Department of Neuroscience, Minneapolis, MN, USA.
Harald J JungeUniversity of Minnesota, Graduate Program in Molecular, Cellular, Developmental Biology, and Genetics, Minneapolis, MN, USA; University of Minnesota, Department of Ophthalmology and Visual Neurosciences, Minneapolis, MN, USA. Electronic address: junge@umn.edu.

Funding

Pilot Project ProgramP30GM145398 · NIGMS · SANFORD RESEARCH/USD · PI W KEITH MISKIMINS · 2023 to 2026
$6.2M
Norrin Signaling in the Retina: Regulation of the Blood-Retina BarrierR01EY024261 · NEI · UNIVERSITY OF MINNESOTA · PI Harald Junge · 2014 to 2026
$4.7M
Predoctoral Training of NeuroscientistsT32NS105604 · NINDS · UNIVERSITY OF MINNESOTA · PI A DAVID REDISH · 2018 to 2026
$3.5M
Investigation of a first-in-class Frizzled4/LRP5 agonist in retinal disease modelsR01EY033316 · NEI · UNIVERSITY OF MINNESOTA · PI Harald Junge · 2022 to 2026
$2.3M
Training Program in Translational Vision SciencesT32EY025187 · NEI · UNIVERSITY OF MINNESOTA · PI Glenn P Lobo, LINDA K. MCLOON · 2016 to 2026
$1.2M
VTA dopamine connectivity and functional responses to drugs of abuseR21DA056728 · NIDA · UNIVERSITY OF MINNESOTA · PI CHEN, ZHE, MEISEL, ROBERT L · 2023 to 2024
$426k
NEI NIH HHS R01 EY024261NEI NIH HHS R01 EY033316NEI NIH HHS T32 EY025187NIDA NIH HHS R21 DA056728NIGMS NIH HHS P30 GM145398NINDS NIH HHS T32 NS105604
6 · The paper itself

Abstract

Frizzled4 (FZD4) is a receptor for Norrin and WNT7A/B ligands, is expressed in endothelial cells (ECs), is required for endothelial blood-central nervous system (CNS) barrier function as well as CNS angiogenesis, and transduces β-catenin-dependent signaling. Despite its fundamental importance in neurovascular biology, including as a drug target, the molecular mechanisms governing FZD4 regulation remain poorly understood. Here, we employed proximity biotinylation to identify proteins that regulate FZD4. We identified ATPase plasma membrane Ca

Indexed as

Central Nervous SystemFrizzled ReceptorsNerve Tissue ProteinsPlasma Membrane Calcium-Transporting ATPasesWnt ProteinsAnimalsCalciumEndothelial CellsEye ProteinsHumansMiceSignal TransductionCalciumEye ProteinsFrizzled ReceptorsFzd4 protein, mouseNdph protein, mouseNerve Tissue ProteinsPlasma Membrane Calcium-Transporting ATPasesWnt7a protein, mouseWnt ProteinsATP2B1blood-brain barrierBlood-retina barriercalciumCP: cell biologyCP: developmental biologyendothelial cellNFATNorrinPMCA1Wnt

Identifiers

PMID42348420
PMCPMC13469879

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.