Evidence map›Paper›PMID 42348176›Full record

ArticleJournal of applied clinical medical physics2026

Pulse‑level characterization of low monitor unit deliveries on a modern linear accelerator using a plastic scintillation detector.

Andrew J White, Poonam Yadav, Indra J Das, Ahtesham U Khan

Abstract read
In one paragraph

Article in Journal of applied clinical medical physics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Andrew J WhiteDepartment of Radiation Oncology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Poonam YadavDepartment of Radiation Oncology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Indra J DasDepartment of Radiation Oncology, Northwestern Memorial Hospital, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA.
Ahtesham U KhanDepartment of Medical Physics, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, Wisconsin, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVariability in low monitor unit (MU) deliveries has been previously documented, but the underlying pulse‑level behavior has not been fully described due to the integrating nature of most conventional detectors. A plastic scintillation detector (PSD) enables direct visualization of MU microstructure by isolating individual linac pulses. PURPOSE: To use a high temporal resolution PSD to characterize pulse‑level MU substructure on a modern linac and quantify how variation in integral pulse magnitude and pulse count influence the reproducibility of low MU and fractional MU deliveries.

methodsA Blue Physics Model 11 PSD was used to measure response from individual linac pulses of a Varian TrueBeam operating at energies of 6 MV, 6 MV FFF, 10 MV, and 10 MV FFF. Initial measurements benchmarked reproducibility in pulse count and dose per pulse by delivering 100 MU at a constant dose rate of 400 MU/min. Subsequent measurements focused on low MU cases, delivering 1-3 MU at dose rates of 5-2400 MU/min.

resultsThe dose per pulse is variable during a single pulse train with a measured coefficient of variation (COV) of up to 13.3%. However, the average dose per pulse across multiple deliveries is stable (< 0.33% COV). This enables highly reproducible readings (< 0.23% COV) for moderate to high MU deliveries. The variation in dose per pulse coupled with a lower number of required pulses leads to challenges when delivering a low number of MUs with FFF beams. Discrepancies in the planned versus delivered MUs were observed on both detectors and the treatment delivery system.

conclusionsTime-resolved analysis shows that dose per pulse fluctuations and the limited number of pulses comprising low MU FFF deliveries lead to measurable variability in delivered MU. These findings characterize the pulsed MU substructure on a modern linac, in which each MU is composed of a finite number of discrete radiation pulses, and quantify the achievable precision of fractional MU delivery, which is fundamentally limited by the dose per pulse (∼0.1 MU for TrueBeam FFF beams).

Indexed as

Particle AcceleratorsPhantoms, ImagingPlasticsRadiometryRadiotherapy Planning, Computer-AssistedScintillation CountingHumansRadiotherapy DosageRadiotherapy, Intensity-ModulatedReproducibility of ResultsPlasticsdosimetrymonitor unitplastic scintillation detectorpulse‐analysistruebeam

Identifiers

PMID42348176
PMCPMC13296819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.