Evidence map›Paper›PMID 42348116›Full record

ArticleCell biochemistry and biophysics2026

The Dual Role of TGF-β and Hypoxia on MMP14-Mediated Invasion in PC3 Cells.

Derya Okuyan, Hanife Aktaş, Fatma Poyrazlı, Sümeyye Aydoğan Türkoğlu

Abstract read
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In one paragraph

Article in Cell biochemistry and biophysics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Derya OkuyanDepartment of Veterinary Medicine, Susurluk Agriculture & Forestry Vocational School, Balıkesir University, Susurluk, Türkiye. derya.okuyan@balikesir.edu.tr.ORCID http://orcid.org/0000-0001-6758-8556
Hanife AktaşDepartment of Molecular Biology and Genetics, Institute of Science, Balıkesir University, Balıkesir, Türkiye.ORCID http://orcid.org/0000-0003-1711-7734
Fatma PoyrazlıDepartment of Molecular Biology and Genetics, Institute of Science, Balıkesir University, Balıkesir, Türkiye.ORCID http://orcid.org/0000-0001-8069-6447
Sümeyye Aydoğan TürkoğluDepartment of Molecular Biology and Genetics, Faculty of Science and Literature, Balıkesir University, Balıkesir, Türkiye.ORCID http://orcid.org/0000-0003-1754-0700

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The MMP14 gene, which encodes the only membrane-bound collagenase, is highly expressed in malignant tumors and plays a decisive role in invasiveness. This study investigated the transcriptional regulation of MMP14 by the TGF-β cytokine and hypoxia in PC3 prostate carcinoma cells. Bioinformatic analysis confirmed the presence of key regulatory elements in the MMP14 promoter, specifically the HRE (for HIF-1α) and SMAD binding sites. Three 5' deletion fragments of the MMP14 promoter (P1: -1251/+75; P2: -649/+75; P3: -176/+75) were cloned for functional analysis. PC3 cells were treated with TGF-β, the hypoxia-mimetic CoCl

Indexed as

Matrix Metalloproteinase 14Transforming Growth Factor betaBinding SitesCell HypoxiaCell Line, TumorCobaltCollagen Type IGene Expression Regulation, NeoplasticHumansHypoxia-Inducible Factor 1, alpha SubunitMaleNeoplasm InvasivenessPC-3 CellsPromoter Regions, GeneticProstatic NeoplasmsCobaltcobaltous chlorideCollagen Type IHypoxia-Inducible Factor 1, alpha SubunitMatrix Metalloproteinase 14MMP14 protein, humanTransforming Growth Factor betaCOL1A1HypoxiaMetastasisMMP14PC3 cellsPromoter regulationTGF-β

Identifiers

PMID42348116
PMCPMC13585980

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.