Evidence map›Paper›PMID 42348058›Full record

ArticleCellular oncology (Dordrecht, Netherlands)2026

Tumor lymph node metastasis chip reveals that the NECTIN3-TIGIT axis promotes melanoma metastasis by enhancing treg cell function and inducing CD8

Cuihao Song, Wenwei Zhu, Yaolin Li, Yuhan Ji, Xiaoling Liu, Yingjie Zhang, Xiaoning Zhang, Fangfang Wei, Hexi Yang, Likeng Liang and 3 more

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Article in Cellular oncology (Dordrecht, Netherlands), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cuihao Song *Department of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Wenwei Zhu *Department of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Yaolin LiDepartment of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Yuhan JiDepartment of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Xiaoling LiuDepartment of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Yingjie ZhangDepartment of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Xiaoning ZhangDepartment of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Fangfang WeiDepartment of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Hexi YangDepartment of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Likeng LiangDepartment of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Shuyan HuangDepartment of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China.
Chengxin LiDepartment of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China. chengxinderm@163.com.
Yong ZhouDepartment of Dermatology, The First Medical Center, Chinese PLA General Hospital, Beijing, 100853, China. zhouypfk@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the role and molecular mechanism of the NECTIN3-TIGIT axis in melanoma lymph node metastasis.

methodsSingle-cell RNA sequencing was performed on human primary melanoma and lymph node metastatic tissues. A tumor lymph node metastasis-on-a-chip model incorporating vascular, lymphatic, and dual-tumor modules was constructed, along with in vitro coculture systems using CD8

resultsThe NECTIN3-TIGIT axis was identified as a core immune ligand-receptor pair in the highmetastasis subgroup, associated with increased regulatory T cell infiltration and CD8

conclusionThe NECTIN3-TIGIT axis promotes melanoma lymph node metastasis by remodeling the immunosuppressive microenvironment. Combined blockade of NECTIN3-TIGIT and PD1 pathways represents a promising therapeutic strategy.

Indexed as

CD8-Positive T-LymphocytesCell Adhesion MoleculesLymphatic MetastasisMelanomaNectinsReceptors, ImmunologicT-Lymphocytes, RegulatoryAnimalsCell Line, TumorFemaleHumansSignal TransductionT-Cell ExhaustionTumor MicroenvironmentCell Adhesion MoleculesNECTIN3 protein, humanNectinsReceptors, ImmunologicTIGIT protein, humanCD8+ T cell exhaustionLymph node metastasisMelanomaNECTIN3-TIGIT axisOrgan-on-a-chipTreg cellsTumor immune microenvironment

Identifiers

PMID42348058
PMCPMC13562484

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.