ArticleHistochemistry and cell biology2026
Eosinophil-associated matrix remodeling in a sterile granulomatous inflammation model: a temporal histopathological analysis.
Article in Histochemistry and cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Eosinophils are increasingly recognized as contributors to tissue remodeling and chronic inflammation, yet their spatiotemporal behavior in sterile granulomatous reactions is incompletely defined. We performed a day 1-14 histopathological time course of a reproducible sterile granuloma induced by implantation of a heat-coagulated egg white pellet into the murine peritoneum. The reaction showed a biphasic inflammatory pattern with early neutrophil predominance followed by a sustained eosinophil-rich phase that persisted through late remodeling. Across time points, lesions progressed from exudative inflammation with prominent fibrin to organized fibroplasia and neovascularization, culminating in collagen-dominated encapsulation by day 14. Eosinophils concentrated at the pellet-tissue interface, frequently displaying apoptosis and degranulation, and occurring in close spatial association with fibroblasts and macrophages. At late time points, the outer granuloma zone contained mononuclear phagocyte/macrophage-like cells alongside dense connective tissue maturation. Together, these findings provide a temporal histopathology atlas of sterile implant granuloma maturation and introduce a semiquantitative framework that summarizes key tissue-composition transitions (fibrinous exudate → fibroplasia/collagen encapsulation) alongside eosinophil enrichment at the pellet-tissue interface.
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